Black G W, Johnston H M, Scott M G
Br J Anaesth. 1977 Sep;49(9):875-80. doi: 10.1093/bja/49.9.875.
Enflurane was used in 150 non-selected patients and was found to be a most satisfactory inhalation anaesthetic. Induction and recovery times were rapid and these characteristics, together with its rather pleasant smell, made it readily acceptable to the patient. Although such features suggest that it would be an ideal agent for children, very high concentrations of enflurane were required to produce adequate anaesthesia in infants and small children. Normal sinus rhythm continued following the injection of adrenaline during enflurane anaesthesia and adequate muscle relaxation was obtained for lower abdominal surgery. The degree of metabolic breakdown of enflurane is considerably less than with other inhalation agents and, if this is reflected in terms of minimal renal and hepatic toxicity, there is every reason to believe that enflurane may be preferable to the volatile anaesthetics currently in use.
安氟醚应用于150例未做挑选的患者，结果发现它是一种非常令人满意的吸入麻醉剂。诱导期和恢复期均很短，这些特点再加上其气味宜人，使患者很容易接受。虽然这些特性表明它对儿童来说是一种理想的麻醉剂，但在婴儿和幼儿中需要很高浓度的安氟醚才能产生足够的麻醉效果。在安氟醚麻醉期间注射肾上腺素后窦性心律仍保持正常，并且为下腹部手术获得了足够的肌肉松弛效果。安氟醚的代谢分解程度比其他吸入麻醉剂要小得多，如果这体现在对肾脏和肝脏的毒性最小方面，那么完全有理由相信安氟醚可能比目前使用的挥发性麻醉剂更可取。
