Böck J C, Knollmann F D, Teltenkötter S, Wlodarczyk W, Mühler A, Vogl T J, Felix R
Strahlenklinik und Poliklinik, Virchow-Klinikum, Medizinische Fakultät, Humboldt-Universität zu Berlin.
Rofo. 1997 Feb;166(2):153-8. doi: 10.1055/s-2007-1015398.
The aim was to demonstrate that intravenous superparamagnetic iron oxide contrast agents improve the delineation of the portal venous system.
The portal venous system of 8 minipigs was demonstrated by a FLASH 2-D MRA-sequence. Scans were acquired before and after intravenous administration of 10 and 20 mumol/kg of a superparamagnetic iron oxide contrast agent (SHU 555 A). Signal intensities were measured in the portal vein and hepatic parenchyma and contrast-to-noise ratios were calculated.
Following a cumulative dose of 10 mumol iron oxide, hepatic parenchymal signal intensity decreased to 67 +/- 6%, following 20 mumol to 29 +/- 4%, and following 40 mumol to 13 +/- 2% of control (p < 0.0001). These effects improved the contrast-to-noise ratio of the portal vein (469 +/- 114%, 858 +/- 243%, and 957 +/- 272% of control in the left portal vein main branch, p = 0.02).
A decrease in hepatic parenchymal signal due to a magnetic susceptibility effect accounts for an improvement of portal venous conspicuity following intravenous administration of iron oxide contrast medium.
旨在证明静脉注射超顺磁性氧化铁造影剂可改善门静脉系统的显示。
采用FLASH 2-D MRA序列对8只小型猪的门静脉系统进行成像。在静脉注射10和20 μmol/kg超顺磁性氧化铁造影剂（SHU 555 A）之前和之后进行扫描。测量门静脉和肝实质的信号强度，并计算对比噪声比。
累积剂量为10 μmol氧化铁后，肝实质信号强度降至对照的67±6%，20 μmol后降至29±4%，40 μmol后降至13±2%（p<0.0001）。这些效应提高了门静脉的对比噪声比（左门静脉主支中分别为对照的469±114%、858±243%和957±272%，p = 0.02）。
静脉注射氧化铁造影剂后，由于磁化率效应导致肝实质信号降低，从而改善了门静脉的显影。
