Richard I H, Schiffer R B, Kurlan R
Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642, USA.
J Neuropsychiatry Clin Neurosci. 1996 Fall;8(4):383-92. doi: 10.1176/jnp.8.4.383.
Anxiety disorders, particularly generalized anxiety, panic, and social phobia, occur in up to 40% of patients with Parkinson's disease (PD). This rate is higher than in normal or other disease comparison populations. Current evidence suggests that anxiety may not be a psychological reaction to the illness but rather may be linked to specific neurobiologic processes accompanying PD. Anxiety in PD often coexists with depression. The optimal pharmacologic treatment for anxiety in patients with PD has not been established, but available information about the use of anxiolytics in PD is reviewed. Further study of the relationship between anxiety and PD may provide an excellent opportunity to clarify the neurobiologic substrate of anxiety itself.
焦虑症，尤其是广泛性焦虑症、恐慌症和社交恐惧症，在高达40%的帕金森病（PD）患者中出现。这一比例高于正常人群或其他疾病对照人群。目前的证据表明，焦虑可能不是对该疾病的心理反应，而是可能与PD伴随的特定神经生物学过程有关。PD患者的焦虑常与抑郁并存。PD患者焦虑症的最佳药物治疗方法尚未确定，但本文综述了有关在PD中使用抗焦虑药的现有信息。对焦虑与PD之间关系的进一步研究可能为阐明焦虑症本身的神经生物学基础提供绝佳机会。
