de Rijk C, Bijl R V
Trimbos-instituut, afd. Geestelijke Gezondheid, Utrecht.
Ned Tijdschr Geneeskd. 1998 Jan 3;142(1):27-31.
To determine the prevalence of cognitive disorder, depression, anxiety and psychotic symptoms in persons with Parkinson's disease in the general population.
Cross-sectional study.
The Netherlands.
Between May and September 1995, a random sample of 384 persons with Parkinson's disease (members of the Parkinson's disease patient organisation plus 24 Dutch nursing home patients) were investigated with the Composite International Diagnostic Interview (CIDI) and the General Health Questionnaire (GHQ-12).
The 1-month prevalence of DSM-III-R psychiatric disorder was 39.1%, of which 13.3% cognitive impairment, 5.5% depression (2.3% major depression and 4.7% dysthymia), and 24.5% anxiety disorder (4.9% agoraphobia and 11.5% social phobia). Psychiatric comorbidity mainly concerned anxiety disorder, in combination with depression (21%) or cognitive disorder (28%). Four out of ten persons who ever had a depression or anxiety disorder, developed the first episode after the onset of Parkinson's disease.
The prevalence of psychiatric disorder in persons with Parkinson's disease was high, compared with figures of the general population, notably for anxiety and cognitive disorder, but not for depression.
确定普通人群中帕金森病患者认知障碍、抑郁、焦虑及精神病性症状的患病率。
横断面研究。
荷兰。
1995年5月至9月期间，采用复合国际诊断访谈（CIDI）和一般健康问卷（GHQ - 12）对384名帕金森病患者（帕金森病患者组织成员加24名荷兰养老院患者）的随机样本进行调查。
DSM - III - R精神障碍的1个月患病率为39.1%，其中认知障碍占13.3%，抑郁占5.5%（重度抑郁占2.3%，心境恶劣占4.7%），焦虑障碍占24.5%（广场恐惧症占4.9%，社交恐惧症占11.5%）。精神共病主要涉及焦虑障碍，常与抑郁（21%）或认知障碍（28%）并存。曾患抑郁或焦虑障碍的患者中，十分之四在帕金森病发病后首次发作。
与普通人群的数据相比，帕金森病患者的精神障碍患病率较高，尤其是焦虑和认知障碍，但抑郁并非如此。
