去甲丙咪嗪（一种内源性儿茶酚胺再摄取抑制剂）对肢端肥大症、高泌乳素血症及对人刺激泌乳素释放的作用。
Effects of nomifensine, an inhibitor of endogenous catecholamine re-uptake, in acromegaly, in hyperprolactinaemia, and against stimulated prolactin release in man.
作者信息
Scanlon M F, Gomez-Pan A, Mora B, Cook D B, Dewar J H, Hildyard A, Weightman D R, Evered D C, Hall R
出版信息
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):191S-197S. doi: 10.1111/j.1365-2125.1977.tb05752.x.
Abstract
- Nomifensine, an inhibitor of endogenous catecholamine re-uptake, did not affect the growth hormone (GH) or prolactin levels in patients with acromegaly or hyperprolactinaemia. It does not, therefore, have any therapeutic role in these conditions at the dosage used in this study. 2. It had no effect on thyrotrophin-releasing hormone (TRH)-induced thyrotrophin (TSH) or prolactin release in males, yet caused marked suppression of monoiodotyrosine (MIT)-induced prolactin release in males but not in females. 3. The significant suppression of MIT-induced prolactin release in males is likely to reflect the dopamine (DA) agonist activity of the drug and its lack of effect in the other situations tested could be dose related. 4. It is proposed that the difference in male and female patterns of prolactin response to MIT after nomifensine, could be due to a "damping" effect of oestrogen on the hypothalamic dopaminergic system.
摘要
- 诺米芬辛是一种内源性儿茶酚胺再摄取抑制剂，对肢端肥大症或高泌乳素血症患者的生长激素（GH）或泌乳素水平没有影响。因此，在本研究使用的剂量下，它在这些病症中没有任何治疗作用。2. 它对男性促甲状腺激素释放激素（TRH）诱导的促甲状腺激素（TSH）或泌乳素释放没有影响，但在男性中却能显著抑制单碘酪氨酸（MIT）诱导的泌乳素释放，而在女性中则无此作用。3. 男性中MIT诱导的泌乳素释放受到显著抑制，这可能反映了该药物的多巴胺（DA）激动剂活性，而在其他测试情况下其无作用可能与剂量有关。4. 有人提出，诺米芬辛后男性和女性对MIT的泌乳素反应模式存在差异，可能是由于雌激素对下丘脑多巴胺能系统的“抑制”作用。
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IMMUNOASSAY OF SERUM GROWTH HORMONE IN ACROMEGALIC PATIENTS.肢端肥大症患者血清生长激素的免疫测定
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Increased serum prolactin after administration of synthetic thyrotropin releasing hormone (TRH) in man.人体注射合成促甲状腺激素释放激素（TRH）后血清催乳素升高。
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Estrogen potentiation of phenothiazine-induced prolactin secretion in man.雌激素对人体中吩噻嗪诱导的催乳素分泌的增强作用。
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