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1
Effects of nomifensine, an inhibitor of endogenous catecholamine re-uptake, in acromegaly, in hyperprolactinaemia, and against stimulated prolactin release in man.去甲丙咪嗪（一种内源性儿茶酚胺再摄取抑制剂）对肢端肥大症、高泌乳素血症及对人刺激泌乳素释放的作用。
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):191S-197S. doi: 10.1111/j.1365-2125.1977.tb05752.x.
2
Inhibition of prolactin secretion by nomifensine in man.
Clin Endocrinol (Oxf). 1980 Mar;12(3):237-41. doi: 10.1111/j.1365-2265.1980.tb02705.x.
3
Effect of nomifensine on cortisol, prolactin and biogenic amines in neurotic depressed patients.诺米芬辛对神经症性抑郁症患者皮质醇、催乳素和生物胺的影响。
Neuropsychobiology. 1983;10(4):209-12. doi: 10.1159/000118013.
4
The effect of nomifensine on thyroid-stimulating hormone (TSH) in normal and hyperprolactinemic subjects.
Neuroendocrinology. 1983 Dec;37(6):406-10. doi: 10.1159/000123584.
5
Benserazide and nomifensine in the diagnosis of prolactin-secreting pituitary adenomas.
Acta Endocrinol (Copenh). 1982 Oct;101(2):171-9. doi: 10.1530/acta.0.1010171.
6
Nomifensine decreases the thyroid-stimulating-hormone response to thyrotropin-releasing-hormone in normal subjects.
J Endocrinol Invest. 1983 Apr;6(2):125-8. doi: 10.1007/BF03350584.
7
Nomifensine-induced pregnancy in a hyperprolactinemic woman.
J Endocrinol Invest. 1982 Mar-Apr;5(2):129-30. doi: 10.1007/BF03350505.
8
Failure of nomifensine to reduce serum prolactin levels in patients with hepatic encephalopathy.诺米芬辛未能降低肝性脑病患者的血清催乳素水平。
J Endocrinol Invest. 1985 Feb;8(1):25-9. doi: 10.1007/BF03350631.
9
Semicircadian rhythm of dopamine release in the mediobasal hypothalamus in awake rats during pseudopregnancy: evidence that a thyrotropin-releasing hormone analogue stimulates dopamine release and thereby inhibits prolactin secretion.假孕期间清醒大鼠下丘脑内侧基底部多巴胺释放的半昼夜节律：促甲状腺激素释放激素类似物刺激多巴胺释放从而抑制催乳素分泌的证据。
Neuroendocrinology. 1995 Nov;62(5):434-43. doi: 10.1159/000127033.
10
Cortisol secretion following nomifensine administration in normal subjects.正常受试者服用诺米芬辛后的皮质醇分泌情况。
Biomedicine. 1979 Nov;31(7):189-91.

引用本文的文献

1
Nomifensine decreases the thyroid-stimulating-hormone response to thyrotropin-releasing-hormone in normal subjects.
J Endocrinol Invest. 1983 Apr;6(2):125-8. doi: 10.1007/BF03350584.
2
Prolactin-lowering and -releasing drugs. Mechanisms of action and therapeutic applications.降低和释放催乳素的药物。作用机制及治疗应用。
Drugs. 1983 Apr;25(4):399-432. doi: 10.2165/00003495-198325040-00004.
3
Neuroendocrine markers of CNS drug effects.中枢神经系统药物作用的神经内分泌标志物。
Br J Clin Pharmacol. 1980 Jul;10(1):5-21. doi: 10.1111/j.1365-2125.1980.tb00497.x.
4
Drug-induced changes in prolactin secretion. Clinical implications.药物引起的催乳素分泌变化。临床意义。
Med Toxicol Adverse Drug Exp. 1988 Nov-Dec;3(6):463-98. doi: 10.1007/BF03259897.
5
Some current aspects of clinical and experimental neuroendocrinology with particular reference to growth hormone, thyrotropin and prolactin.临床与实验神经内分泌学的一些当前研究方面，特别涉及生长激素、促甲状腺激素和催乳素。
J Endocrinol Invest. 1979 Jul-Sep;2(3):307-31. doi: 10.1007/BF03350424.

本文引用的文献

1
IMMUNOASSAY OF SERUM GROWTH HORMONE IN ACROMEGALIC PATIENTS.肢端肥大症患者血清生长激素的免疫测定
Br Med J. 1964 Nov 14;2(5419):1229-32. doi: 10.1136/bmj.2.5419.1229.
2
Inhibitors of purified beef adrenal tyrosine hydroxylase.纯化牛肾上腺酪氨酸羟化酶的抑制剂。
Biochem Pharmacol. 1965 May;14(5):837-45. doi: 10.1016/0006-2952(65)90103-6.
3
[Inhibition of prolactin secretion by ergocornine and 2-Br-alpha-ergocryptine: direct action on the hypophysis in culture].麦角隐亭和2-溴-α-麦角隐亭对催乳素分泌的抑制作用：对培养垂体的直接作用
Ann Endocrinol (Paris). 1971 Jan-Feb;32(1):188-92.
4
Radioimmunoassay of human serum thyrotrophin.人血清促甲状腺素的放射免疫测定
Br Med J. 1971 Mar 13;1(5749):582-5. doi: 10.1136/bmj.1.5749.582.
5
Levodopa suppression of prolactin in nonpuerperal galactorrhea.左旋多巴对非产褥期溢乳症患者催乳素的抑制作用
N Engl J Med. 1971 Nov 18;285(21):1160-3. doi: 10.1056/NEJM197111182852102.
6
Direct inhibition by ergocornine of pituitary prolactin release.麦角柯宁碱对垂体催乳素释放的直接抑制作用。
Endocrinology. 1971 Jul;89(1):229-33. doi: 10.1210/endo-89-1-229.
7
Increased serum prolactin after administration of synthetic thyrotropin releasing hormone (TRH) in man.人体注射合成促甲状腺激素释放激素（TRH）后血清催乳素升高。
J Clin Endocrinol Metab. 1971 Dec;33(6):996-8. doi: 10.1210/jcem-33-6-996.
8
Decreased plasma growth hormone (GH) levels in acromegalics following CB 154(2-Br-alpha ergocryptine) administration.
J Clin Endocrinol Metab. 1974 May;38(5):910-2. doi: 10.1210/jcem-38-5-910.
9
Estrogen potentiation of phenothiazine-induced prolactin secretion in man.雌激素对人体中吩噻嗪诱导的催乳素分泌的增强作用。
J Clin Endocrinol Metab. 1973 Dec;37(6):977-80. doi: 10.1210/jcem-37-6-977.
10
The inhibition of prolactin secretion in man by CB-154 (2-Br-alpha-ergocryptine).CB - 154（2 - 溴 - α - 麦角隐亭）对人体催乳素分泌的抑制作用。
J Clin Endocrinol Metab. 1972 Nov;35(5):768-71. doi: 10.1210/jcem-35-5-768.

去甲丙咪嗪（一种内源性儿茶酚胺再摄取抑制剂）对肢端肥大症、高泌乳素血症及对人刺激泌乳素释放的作用。

Effects of nomifensine, an inhibitor of endogenous catecholamine re-uptake, in acromegaly, in hyperprolactinaemia, and against stimulated prolactin release in man.

作者信息

Scanlon M F, Gomez-Pan A, Mora B, Cook D B, Dewar J H, Hildyard A, Weightman D R, Evered D C, Hall R

出版信息

Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):191S-197S. doi: 10.1111/j.1365-2125.1977.tb05752.x.

DOI:10.1111/j.1365-2125.1977.tb05752.x
PMID:911652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1429125/
Abstract
  1. Nomifensine, an inhibitor of endogenous catecholamine re-uptake, did not affect the growth hormone (GH) or prolactin levels in patients with acromegaly or hyperprolactinaemia. It does not, therefore, have any therapeutic role in these conditions at the dosage used in this study. 2. It had no effect on thyrotrophin-releasing hormone (TRH)-induced thyrotrophin (TSH) or prolactin release in males, yet caused marked suppression of monoiodotyrosine (MIT)-induced prolactin release in males but not in females. 3. The significant suppression of MIT-induced prolactin release in males is likely to reflect the dopamine (DA) agonist activity of the drug and its lack of effect in the other situations tested could be dose related. 4. It is proposed that the difference in male and female patterns of prolactin response to MIT after nomifensine, could be due to a "damping" effect of oestrogen on the hypothalamic dopaminergic system.
摘要
  1. 诺米芬辛是一种内源性儿茶酚胺再摄取抑制剂，对肢端肥大症或高泌乳素血症患者的生长激素（GH）或泌乳素水平没有影响。因此，在本研究使用的剂量下，它在这些病症中没有任何治疗作用。2. 它对男性促甲状腺激素释放激素（TRH）诱导的促甲状腺激素（TSH）或泌乳素释放没有影响，但在男性中却能显著抑制单碘酪氨酸（MIT）诱导的泌乳素释放，而在女性中则无此作用。3. 男性中MIT诱导的泌乳素释放受到显著抑制，这可能反映了该药物的多巴胺（DA）激动剂活性，而在其他测试情况下其无作用可能与剂量有关。4. 有人提出，诺米芬辛后男性和女性对MIT的泌乳素反应模式存在差异，可能是由于雌激素对下丘脑多巴胺能系统的“抑制”作用。