Ball J, Freedman L, Sissons H A
Br J Cancer. 1977 Aug;36(2):254-68. doi: 10.1038/bjc.1977.185.
A study of 40 cases of malignant round-cell tumour of one was made from the files of the Cancer Research Campaign's Bone Tumour Panel. Five pathologists made a careful study of observer error, involving repeated examination of routine paraffin sections, to determine whether the cases were a homogeneous group or a collection of differing sub-groups. Cell outline, nuclear staining, nuclear pleomorphism, conspicuous nucleoli, reticulin pattern and intracellular glycogen were the histological features selected for study. For each feature, the results were analysed to assess the importance of differences between tumours, between samples of tissue from the same tumour, and between observers. It is concluded that round-cell tumours of bone are a heterogeneous group, although completely distinct sub-groups could not be identified. Certain histological features tend to be associated, and it is reasonable to distinguish on histological grounds between Ewing's sarcoma and reticulum-cell sarcoma, although some tumours are not typical of either group.
对癌症研究运动骨肿瘤专题小组档案中的40例单发性恶性圆形细胞瘤病例进行了研究。五位病理学家对观察者误差进行了仔细研究，包括对常规石蜡切片的反复检查，以确定这些病例是一个同质组还是不同亚组的集合。细胞轮廓、核染色、核多形性、明显核仁、网状纤维模式和细胞内糖原是选择用于研究的组织学特征。对于每个特征，对结果进行分析，以评估肿瘤之间、同一肿瘤的组织样本之间以及观察者之间差异的重要性。得出的结论是，骨圆形细胞瘤是一个异质组，尽管无法识别出完全不同的亚组。某些组织学特征往往相互关联，从组织学角度区分尤因肉瘤和网状细胞肉瘤是合理的，尽管有些肿瘤不属于这两组中的任何一组。
