Grant K, Bell C, Han V
Institut Alfred-Fessard, CNRS, Gif-sur-Yvette, France.
J Physiol Paris. 1996;90(3-4):233-7. doi: 10.1016/s0928-4257(97)81430-1.
Cerebellum-like sensory structures in different groups of first have been shown to generate a negative image of predictable features of the sensory input. We show here that anti-Hebbian plasticity is present at the synapse between parallel fibers and Purkinje-like cells which could mediate the generation of these negative images. We also show that this synapse is capable of bidirectional changes in synaptic efficacy with the direction of change depending on the precise temporal relation of presynaptic input and postsynaptic spike during pairing. Parallel fiber-evoked EPSPs are depressed after pairings in which the EPSP begins between 0 and 60 ms before the postsynaptic spike but are enhanced at other delays, including those in which the postsysnaptic spike occurs just before the EPSP.
首先，不同组中的类小脑感觉结构已被证明能生成感觉输入可预测特征的负像。我们在此表明，反赫布可塑性存在于平行纤维与类浦肯野细胞之间的突触处，这可能介导了这些负像的生成。我们还表明，该突触能够在突触效能上发生双向变化，变化方向取决于配对期间突触前输入与突触后峰电位的精确时间关系。在突触后峰电位前0至60毫秒之间开始出现兴奋性突触后电位（EPSP）的配对后，平行纤维诱发的EPSP会受到抑制，但在其他延迟情况下会增强，包括突触后峰电位恰好在EPSP之前出现的那些情况。
