Hudson N, Duffy C M, Rauch J, Paquin J D, Esdaile J M
Division of Rheumatology, Montreal General Hospital, PQ, Canada.
Lupus. 1997;6(1):68-71. doi: 10.1177/096120339700600110.
The first case of primary antiphospholipid syndrome associated with recurrent life-threatening haemorrhages, due to the coexistence of acquired prothrombin deficiency, is described. Attention is drawn to the difficulty in diagnosing this situation, and therapeutic options are reviewed. Evidence is presented that implicates prothrombin as the protein cofactor for this lupus anticoagulant.
本文描述了首例因获得性凝血酶原缺乏共存而导致复发性危及生命出血的原发性抗磷脂综合征病例。文中提请注意诊断这种情况的困难，并回顾了治疗选择。有证据表明凝血酶原是这种狼疮抗凝物的蛋白辅因子。
