Avances C, Mottet N, Chapuis H, Dagues F, Ben Naoum K, Louis J F, Costa P, Marty-Double C, Navratil H
Service d'Urologie Andrologie, Hôpital Gaston Doumergue, Nîmes, France.
Prog Urol. 1997 Feb;7(1):85-7.
Neuroendocrine bladder tumours are exceptional, and the positive diagnosis is only established when they are already large and advanced. We report an original case in view of its small dimensions. We discuss the differential diagnosis (mainly bladder metastases from lung cancer) and pathological specificities, particularly the value of epithelial immunolabelling allowing exclusion of lymphoma. Because of the similarities with bronchial neuroendocrine tumours, the potential value of serum NSE assay should be emphasized. Combined surgery-cisplatin-based adjuvant chemotherapy is recommended.
神经内分泌膀胱肿瘤较为罕见，只有在肿瘤已经很大且处于晚期时才能做出阳性诊断。鉴于该病例肿瘤尺寸较小，我们在此报告这一独特病例。我们讨论了鉴别诊断（主要是肺癌的膀胱转移）和病理特征，特别是上皮免疫标记在排除淋巴瘤方面的价值。鉴于其与支气管神经内分泌肿瘤的相似性，应强调血清神经元特异性烯醇化酶（NSE）检测的潜在价值。建议采用手术联合以顺铂为基础的辅助化疗。
