Hahn A F
University of Western Ontario, London, Canada.
Baillieres Clin Neurol. 1996 Oct;5(3):627-44.
GBS is an acute immune-mediated neuropathy which, in one-third of cases, leads to total paralysis requiring ICU admission for assisted ventilation and management of autonomic cardiovascular instability. The management can be challenging and even with most expert care and modern ICU facilities the mortality remains at 5-8%. This chapter gives an outline of the natural history and pathophysiology of the condition with emphasis on newer concepts. Guidelines are given for the management of patients prior to and during the admission to an ICU by highlighting the potential complications. An up-to-date account is given on the specific immunomodulatory therapies.
吉兰-巴雷综合征（GBS）是一种急性免疫介导性神经病，三分之一的病例会导致完全性瘫痪，需要入住重症监护病房（ICU）进行辅助通气以及处理自主心血管功能不稳定。其治疗颇具挑战性，即便给予最专业的护理和配备现代化的ICU设施，死亡率仍达5% - 8%。本章概述了该疾病的自然病程和病理生理学，重点介绍了一些新的概念。通过强调潜在并发症，给出了患者在入住ICU之前及期间的管理指南。还提供了关于特定免疫调节疗法的最新情况。
