萘普生钠对运动诱发的肌肉功能障碍、损伤和酸痛的疗效。

Efficacy of naproxen sodium for exercise-induced dysfunction muscle injury and soreness.

作者信息

Dudley G A, Czerkawski J, Meinrod A, Gillis G, Baldwin A, Scarpone M

机构信息

Department of Exercise Science, University of Georgia, Athens 30602, USA.

出版信息

Clin J Sport Med. 1997 Jan;7(1):3-10. doi: 10.1097/00042752-199701000-00002.

DOI:10.1097/00042752-199701000-00002

PMID:9117523

Abstract

OBJECTIVE

To examine the efficacy of naproxen sodium for exercise-induced dysfunction, muscle injury, and soreness.

DESIGN

Double-blind crossover.

SETTING

Community.

PARTICIPANTS

Eight young adult, healthy males.

INTERVENTIONS

Ten sets of seven to 10 eccentric actions with each quadriceps femoris with a load equal to 85% of the eccentric one repetition maximum (1RM) followed by 10 days of naproxen sodium or placebo.

MAIN OUTCOME MEASURES

Concentric 1RM; cross-sectional area (CSA) and spin-spin relaxation time (T2) of quadriceps femoris, and subjective rating of thigh soreness pre- and 1, 4, and 10 days postexercise; subjective rating of ability to sleep or perform morning activities daily during recovery.

RESULTS

Concentric 1RM was reduced by (p = 0.0001) 41% day 1 of recovery; by day 4 of recovery, it had increased (p = 0.0145) to 24% below baseline in the drug trial, but did not change for the placebo trial. By day 10 of recovery, concentric 1RM was 16 and 26% below (p = 0.0001) baseline for the drug and placebo trials, respectively. Quadriceps femoris CSA and T2 were increased (p < or = 0.0250) after exercise, with the greatest (p = 0.0008) responses evident on day 4 of recovery. At this time, each variable showed greater increases (p < or = 0.0129) for the placebo than for the drug trial 8 vs. 5 and 26 vs. 15%, respectively). The CSA of the quadriceps femoris showing an elevated T2 was 27 and 37% greater (p < or = 0.0085) for the placebo than for the drug trial on days 1 and 4 of recovery, respectively. The percentage of quadriceps femoris CSA with an elevated T2 (40%) was 1/3 greater (p < or = 0.0138) for the placebo than for the drug trial on these days. Thigh soreness was lower (day 4, p = 0.0087) and the ability to sleep or perform morning activities was less (p < or = 0.0030) compromised (days 3 and 4) during recovery in the drug trial.

CONCLUSIONS

The results suggest that naproxen sodium improved recovery after eccentrically biased exercise, probably by attenuating expression of the inflammatory response to muscle injury.

摘要

目的

研究萘普生钠对运动诱发的功能障碍、肌肉损伤和酸痛的疗效。

设计

双盲交叉试验。

地点

社区。

参与者

8名健康的年轻成年男性。

干预措施

对每侧股四头肌进行10组，每组7至10次离心动作，负荷相当于离心一次重复最大值（1RM）的85%，随后10天服用萘普生钠或安慰剂。

主要观察指标

向心1RM；股四头肌的横截面积（CSA）和自旋-自旋弛豫时间（T2），以及运动前、运动后第1、4和10天大腿酸痛的主观评分；恢复期间每日睡眠或进行晨练活动能力的主观评分。

结果

恢复第1天，向心1RM降低（p = 0.0001）41%；在药物试验中，恢复第4天，向心1RM增加（p = 0.0145）至比基线低24%，但在安慰剂试验中未发生变化。恢复第10天，药物试验和安慰剂试验中向心1RM分别比基线低16%和26%（p = 0.0001）。运动后股四头肌CSA和T2增加（p≤0.0250），恢复第4天反应最大（p = 0.0008）。此时，安慰剂组各变量的增加幅度更大（p≤0.0129），分别为8%对5%和26%对15%。恢复第1天和第4天，T2升高的股四头肌CSA，安慰剂组分别比药物试验组大27%和37%（p≤0.0085）。这些天里，T2升高的股四头肌CSA百分比（40%），安慰剂组比药物试验组大1/3（p≤0.0138）。药物试验恢复期间，大腿酸痛较轻（第4天，p = 0.0087），睡眠或进行晨练活动的能力受影响较小（第3天和第4天，p≤0.0030）。