健康老年人离心运动后的非甾体抗炎治疗。

Nonsteroidal anti-inflammatory therapy after eccentric exercise in healthy older individuals.

作者信息

Baldwin A C, Stevenson S W, Dudley G A

机构信息

Department of Exercise Science, The University of Georgia, 300 River Road, Athens, GA 30602-3654, USA.

出版信息

J Gerontol A Biol Sci Med Sci. 2001 Aug;56(8):M510-3. doi: 10.1093/gerona/56.8.m510.

DOI:10.1093/gerona/56.8.m510

PMID:11487604

Abstract

BACKGROUND

Aging is associated with greater susceptibility to muscle injury and soreness after exercise. Although elderly persons regularly consume nonsteroidal anti-inflammatory drugs (NSAIDs), it is not clear that NSAIDs alleviate muscle dysfunction and/or inflammation following injurious exercise.

METHODS

In this double-blind crossover study, 10 men and 5 women (aged 60 +/- 2 years, mean +/- SE) consumed naproxen sodium or placebo for 10 days after performing 64 unilateral eccentric (ECC) knee extensions using 75% of the ECC 1-repetition maximum. Strength was measured before, 3 days after, and 10 days after each bout. Injury and soreness were assessed using magnetic resonance images of m. quadriceps femoris (QF) and a visual analog scale.

RESULTS

Three days after exercise, concentric strength loss was greater for placebo (-32 +/- 9%) than NSAID (-6 +/- 8%; p =.0064). Likewise, isometric strength declined less for NSAID than placebo (-12 +/- 7% vs -24 +/- 4%; p =.0213), and thigh soreness while rising from a chair was greater for placebo (p < or =.0393) than NSAID (43 +/- 7 mm vs 26 +/- 7 mm). QF cross-sectional area (cm(2)) showing elevated T(2) was 27% and 35% greater (p < or =.0096) for placebo on Days 3 and 10, respectively.

CONCLUSIONS

Naproxen sodium attenuated muscle injury, strength loss, and soreness following ECC exercise in older individuals and may be beneficial during the early stages of increased physical activity.

摘要

背景

衰老与运动后肌肉损伤和酸痛的易感性增加有关。尽管老年人经常服用非甾体抗炎药（NSAIDs），但尚不清楚NSAIDs是否能缓解损伤性运动后的肌肉功能障碍和/或炎症。

方法

在这项双盲交叉研究中，10名男性和5名女性（年龄60±2岁，均值±标准误）在以75%的离心1次最大重复量进行64次单侧离心（ECC）膝关节伸展运动后，服用萘普生钠或安慰剂10天。在每次运动前、运动后3天和10天测量力量。使用股四头肌（QF）的磁共振图像和视觉模拟量表评估损伤和酸痛情况。

结果

运动后3天，安慰剂组的向心力量损失（-32±9%）大于萘普生钠组（-6±8%；p = 0.0064）。同样，萘普生钠组的等长力量下降幅度小于安慰剂组（-12±7%对-24±4%；p = .0213），从椅子上起身时安慰剂组的大腿酸痛程度（p≤0.0393）大于萘普生钠组（43±7毫米对26±7毫米）。在第3天和第10天，安慰剂组显示T2升高的QF横截面积（平方厘米）分别大27%和35%（p≤0.0096）。