Pearson R C
Department of Biomedical Science, University of Sheffield.
Neurodegeneration. 1996 Dec;5(4):429-34. doi: 10.1006/neur.1996.0058.
The hypothesis that the distribution of neurodegeneration in Alzheimer's disease results from the spread of the pathology via anatomical connections is reviewed in the light of recent advances in knowledge of the connectivity of the cerebral cortex. Current understanding of cortical connections allows a more detailed examination of the distribution of pathology, particularly neurofibrillary tangles, in relation to this hypothesis. In particular, quantitative assessment of corticocortical pathways opens up the possibility of specific testing of the hypothesis. Theoretical considerations are discussed, and a predicted spread of pathology beginning in the olfactory centres of the medial temporal lobe and spreading retrogradely via known pathways is presented.
鉴于大脑皮质连接性知识的最新进展，对阿尔茨海默病中神经退行性变的分布是由病理通过解剖学连接扩散所致这一假说进行了综述。目前对皮质连接的理解使得能够更详细地研究与该假说相关的病理分布，特别是神经原纤维缠结。尤其是，对皮质-皮质通路的定量评估为该假说的具体检验开辟了可能性。讨论了理论考量，并呈现了一种始于内侧颞叶嗅觉中枢并通过已知通路逆行扩散的病理预测扩散情况。
