Trissel L A, Gilbert D L, Martinez J F
Division of Pharmacy, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.
Am J Health Syst Pharm. 1997 Jan 1;54(1):56-60. doi: 10.1093/ajhp/54.1.56.
The compatibility of granisetron hydrochloride with selected other drugs during simulated Y-site administration was studied. Five milliliters of granisetron 50 micrograms/mL (as the hydrochloride) in 5% dextrose injection was combined with 5 mL of each of 91 secondary additives, including antineoplastics, anti-infectives, and supportive care drugs, in 5% dextrose injection or (if necessary to avoid incompatibility with the diluent) 0.9% sodium chloride injection. Visual examinations were performed with the unaided eye in fluorescent light and in high-intensity monodirectional light to enhance visualization of small particles and low-level turbidity. The turbidity of each solution was measured as well. Particle sizing and counting were performed for selected solutions. Evaluations were performed initially and at one and four hours. Nearly all the test drugs were compatible with granisetron during the four-hour observation period. The granisetron-amphotericin B combination had an unacceptable increase in turbidity upon being mixed. During simulated Y-site administration, granisetron 50 micrograms/mL (as the hydrochloride) in 5% dextrose injection was compatible with 90 of 91 drugs and combination drugs for four hours at room temperature; the exception was amphotericin B.
研究了盐酸格拉司琼在模拟Y型接口给药时与其他选定药物的配伍性。将5毫升50微克/毫升（以盐酸盐形式）的格拉司琼加入5%葡萄糖注射液中，再分别与5毫升91种二次添加剂混合，这些添加剂包括5%葡萄糖注射液中的抗肿瘤药、抗感染药和支持治疗药物，或（如有必要避免与稀释剂不相容）0.9%氯化钠注射液中的上述药物。在荧光灯和高强度单向光下用肉眼进行目视检查，以增强对小颗粒和低水平浑浊度的观察。同时测量每种溶液的浑浊度。对选定的溶液进行粒度分析和颗粒计数。在最初以及1小时和4小时时进行评估。在4小时观察期内，几乎所有受试药物都与格拉司琼配伍。格拉司琼与两性霉素B混合后浑浊度增加，无法接受。在模拟Y型接口给药时，5%葡萄糖注射液中50微克/毫升（以盐酸盐形式）的格拉司琼在室温下与91种药物及复方药物中的90种在4小时内配伍；例外的是两性霉素B。
