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晚期癌症患者的瘙痒症通过格拉司琼持续输注成功治愈。

Pruritus in a patient with advanced cancer successfully treated with continuous infusion of granisetron.

作者信息

Porzio Giampiero, Aielli Federica, Narducci Filomena, Cannita Katia, Piccolo Domenico, Marchetti Paolo

机构信息

Supportive Care and Rehabilitation Unit, Medical Oncology Department, University of L'Aquila, L'Aquila, Italy.

出版信息

Support Care Cancer. 2004 Mar;12(3):208-9. doi: 10.1007/s00520-003-0581-2. Epub 2004 Jan 21.

DOI:10.1007/s00520-003-0581-2
PMID:14735336
Abstract

We present a case of a patient with advanced cancer affected by severe pruritus not related with cholestasis and/or opioid treatment successfully treated with subcutaneous continuous infusion of granisetron (3 mg/24 h diluted in normal saline via a disposable elastomeric infusion device). Confirmatory studies with a control group are warranted to confirm these preliminary results.

摘要

我们报告了一例晚期癌症患者，其患有严重瘙痒症，与胆汁淤积和/或阿片类药物治疗无关，通过皮下持续输注格拉司琼（3毫克/24小时，经一次性弹性输注装置用生理盐水稀释）成功治愈。有必要进行对照组的验证性研究以证实这些初步结果。

相似文献

1
Pruritus in a patient with advanced cancer successfully treated with continuous infusion of granisetron.晚期癌症患者的瘙痒症通过格拉司琼持续输注成功治愈。
Support Care Cancer. 2004 Mar;12(3):208-9. doi: 10.1007/s00520-003-0581-2. Epub 2004 Jan 21.
2
5HT3 receptor antagonists and pruritus due to cholestasis.5-羟色胺3受体拮抗剂与胆汁淤积引起的瘙痒
Palliat Med. 1996 Jan;10(1):54. doi: 10.1177/026921639601000112.
3
[Do 5HT-3 receptor antagonists ameliorate cholestatic pruritus?].5-羟色胺-3受体拮抗剂能改善胆汁淤积性瘙痒吗？
An Med Interna. 1995 Aug;12(8):411.
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Reduction of severity of pruritus after elective caesarean section under spinal anaesthesia with subarachnoid morphine: a randomised comparison of prophylactic granisetron and ondansetron.脊髓麻醉下选择性剖宫产术后瘙痒严重程度的减轻：预防性格拉司琼和昂丹司琼的随机比较。
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Granisetron or ondansetron for prevention of subarachnoid morphine-induced pruritus after cesarean delivery.格拉司琼或昂丹司琼预防剖宫产术后蛛网膜下腔注射吗啡所致瘙痒。
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本文引用的文献

1
Severe pruritus in a haemodialysed patient: dramatic improvement with granisetron.一名血液透析患者的严重瘙痒：格拉司琼使其显著改善。
Br J Dermatol. 2003 Feb;148(2):376-7. doi: 10.1046/j.1365-2133.2003.05097_11.x.
2
A randomized, placebo-controlled, double-blind trial of ondansetron in renal itch.一项关于昂丹司琼治疗肾性瘙痒的随机、安慰剂对照、双盲试验。
Br J Dermatol. 2003 Feb;148(2):314-7. doi: 10.1046/j.1365-2133.2003.05172.x.
3
Pruritus in cancer patients.癌症患者的瘙痒
Cancer Treat Rev. 2001 Oct;27(5):305-12. doi: 10.1053/ctrv.2001.0231.
4
Understanding pruritus in systemic disease.
J Pain Symptom Manage. 2001 Feb;21(2):151-68. doi: 10.1016/s0885-3924(00)00256-6.
5
Compatibility of granisetron hydrochloride with selected drugs during simulated Y-site administration.盐酸格拉司琼在模拟 Y 型静脉给药过程中与选定药物的配伍性。
Am J Health Syst Pharm. 1997 Jan 1;54(1):56-60. doi: 10.1093/ajhp/54.1.56.
6
Relief of cholestatic pruritus by a novel class of drugs: 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists: effectiveness of ondansetron.一类新型药物缓解胆汁淤积性瘙痒：5-羟色胺3型（5-HT3）受体拮抗剂：昂丹司琼的有效性
Pain. 1995 Apr;61(1):33-37. doi: 10.1016/0304-3959(94)00145-5.
7
Stability of granisetron hydrochloride in a disposable elastomeric infusion device.盐酸格拉司琼在一次性弹性输液装置中的稳定性
Am J Health Syst Pharm. 1995 Jul 15;52(14):1541-3. doi: 10.1093/ajhp/52.14.1541.