Cytomegalovirus infection and Joubert's syndrome.

A patient with serologically proven congenital cytomegalovirus (CMV) infection is described with periventricular calcifications on CT. The condition was associated with the typical cerebellar changes of clinicoradiologically proven Joubert's syndrome. Although this may be a chance association only, the condition raised the question if an early intrauterine CMV infection, which affects the cerebellum, may contribute to the occurrence of Joubert's syndrome.