Klei T R, French D D, Chapman M R, McClure J R, Dennis V A, Taylor H W, Hutchinson G W
Department of Veterinary Science, Louisiana State University, Baton Rouge 70808, USA.
Equine Vet J Suppl. 1989 Jun(7):2-7. doi: 10.1111/j.2042-3306.1989.tb05645.x.
The long-term efficacy of an irradiation attenuated larval (L3) vaccine against Strongylus vulgaris was tested in ponies which were reared on pasture. Prior to foaling, mares were divided into two groups. One group of mares and foals received regular (eight weekly) treatment with ivermectin and the second group remained untreated. Half the foals in each pasture group were vaccinated at eight to ten weeks of age. Foals were weaned at three to four months of age and maintained on separate pastures. At eight to ten months of age, ponies were placed in box stalls and half of each treatment group were challenged with S. vulgaris (5 x 1000 L3). Clinical signs and lesions typical of acute verminous arteritis were found at necropsy in the ivermectin treated non-vaccinated challenged yearlings. Ivermectin treated vaccinated challenged yearlings did not show these clinical signs, had markedly reduced to absent arterial lesions and showed an 89 per cent reduction in arterial larval burdens post mortem. Significant differences in clinical signs, arterial lesions or arterial larval burdens were not seen between vaccinated and non-vaccinated foals reared without benefit of ivermectin treatment.
在牧场饲养的小马驹中测试了辐照减毒幼虫（L3）疫苗对普通圆线虫的长期疗效。在产驹前，母马被分为两组。一组母马和马驹接受定期（每八周一次）伊维菌素治疗，第二组不进行治疗。每个牧场组中有一半的马驹在8至10周龄时接种疫苗。马驹在3至4个月龄时断奶，并饲养在单独的牧场上。在8至10个月龄时，将小马驹安置在厩舍中，每个治疗组中有一半受到普通圆线虫（5×1000条L3）的攻击。在尸检时，接受伊维菌素治疗但未接种疫苗且受到攻击的一岁马中发现了典型的急性蠕虫性动脉炎的临床症状和病变。接受伊维菌素治疗且接种疫苗并受到攻击的一岁马没有出现这些临床症状，动脉病变明显减轻或消失，并且死后动脉幼虫负荷降低了89%。在未接受伊维菌素治疗的情况下饲养的接种疫苗和未接种疫苗的马驹之间，在临床症状、动脉病变或动脉幼虫负荷方面未观察到显著差异。
