Campbell I L, Gold L H
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA.
Mol Psychiatry. 1996 May;1(2):105-20.
Converging advances in the fields of molecular biology, molecular genetics, cellular biology and embryology have given researchers the tools for the targeted delivery and stable germline transmission of foreign genes (transgenes) in the mouse. In the realm of neuropsychiatry, this so-named transgenic technology has begun to catapult our knowledge of the genetic, molecular and cellular mechanisms in the brain that are linked to a variety of mental disorders as well as normal behavioral processes such as learning and memory. Moreover, the potential for transgenic technology to develop more precise animal models of specific human neuropsychiatric disorders will likely lead to the identification of novel targets for therapeutic intervention and facilitate the preclinical testing of new therapeutic agents. This article examines key issues and highlights recent developments pertaining to the transgenic modeling of neuropsychiatric disorders.
分子生物学、分子遗传学、细胞生物学和胚胎学领域的协同进展，为研究人员提供了在小鼠中靶向递送和稳定种系传递外源基因（转基因）的工具。在神经精神病学领域，这种所谓的转基因技术已开始极大地增进我们对大脑中与多种精神障碍以及学习和记忆等正常行为过程相关的遗传、分子和细胞机制的了解。此外，转基因技术开发更精确的特定人类神经精神疾病动物模型的潜力，可能会促成新型治疗干预靶点的识别，并促进新治疗药物的临床前测试。本文探讨了与神经精神疾病转基因建模相关的关键问题，并重点介绍了近期的进展。
