Dosemeci M, Yin S N, Linet M, Wacholder S, Rothman N, Li G L, Chow W H, Wang Y Z, Jiang Z L, Dai T R, Zhang W U, Chao X J, Ye P Z, Kou Q R, Fan Y H, Zhang X C, Lin X F, Meng J F, Zho J S, Blot W J, Hayes R B
Division of Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Environ Health Perspect. 1996 Dec;104 Suppl 6(Suppl 6):1343-7. doi: 10.1289/ehp.961041343.
We present a validation study of a quantitative retrospective exposure assessment method used in a follow-up study of workers exposed to benzene. Assessment of exposure to benzene was carried out in 672 factories in 12 cities in China. Historical exposure data were collected for 3179 unique job titles. The basic unit for exposure assessment was a factory/work unit/job title combination over seven periods between 1949 and 1987. A total of 18,435 exposure estimates was developed, using all available historical information, including 8477 monitoring data. Overall, 38% of the estimates were based on benzene monitoring data. The highest time-weighted average exposures were observed for the rubber industry (30.7 ppm) and for rubber glue applicators (52.6 ppm). Because of its recognized link with benzene exposure, the association between a clinical diagnosis of benzene poisoning and benzene exposure was evaluated to validate the assessment method that we used in the cohort study. Our confidence in the assessment method is supported by the observation of a strong positive trend between benzene poisoning and various measures, especially recent intensity of exposure to benzene.
我们展示了一项在苯接触工人随访研究中使用的定量回顾性暴露评估方法的验证研究。在中国12个城市的672家工厂中开展了苯暴露评估。收集了3179个不同职位的历史暴露数据。暴露评估的基本单位是1949年至1987年期间七个时间段内的工厂/工作单位/职位组合。利用所有可用的历史信息，包括8477份监测数据，共得出18435个暴露估计值。总体而言，38%的估计值基于苯监测数据。橡胶行业（30.7 ppm）和涂胶工人（52.6 ppm）的时间加权平均暴露最高。由于苯中毒的临床诊断与苯暴露之间存在公认的联系，因此对苯中毒的临床诊断与苯暴露之间的关联进行了评估，以验证我们在队列研究中使用的评估方法。苯中毒与各种指标之间，尤其是近期苯暴露强度之间呈现出强烈的正相关趋势，这一观察结果支持了我们对评估方法的信心。
