Hayes R B, Yin S N, Dosemeci M, Li G L, Wacholder S, Chow W H, Rothman N, Wang Y Z, Dai T R, Chao X J, Jiang Z L, Ye P Z, Zhao H B, Kou Q R, Zhang W Y, Meng J F, Zho J S, Lin X F, Ding C Y, Li C Y, Zhang Z N, Li D G, Travis L B, Blot W J, Linet M S
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-7368, USA.
Environ Health Perspect. 1996 Dec;104 Suppl 6(Suppl 6):1349-52. doi: 10.1289/ehp.961041349.
A large cohort of 74,828 benzene-exposed and 35,805 nonexposed workers employed between 1972 and 1987 in 12 cities in China was followed to determine mortality from all causes. Benzene-exposed study subjects were employed in a variety of occupations including coating applications, and rubber, chemical, and shoe production. Mortality was slightly increased among workers with greater cumulative exposure to benzene (ptrend < 0.05), but this excess was largely due to cancer deaths (ptrend < 0.01). Deaths due to lymphatic and hematopoietic malignancies (ptrend = 0.01) and lung cancer (ptrend = 0.01) increased with increasing cumulative exposure to benzene. Investigations continue to relate benzene exposure to specific lymphatic and hematopoietic malignancies and other causes of death.
对1972年至1987年间在中国12个城市工作的74828名接触苯的工人和35805名未接触苯的工人组成的大型队列进行随访，以确定各种原因导致的死亡率。接触苯的研究对象从事多种职业，包括涂料应用、橡胶、化工和制鞋生产。累积接触苯量较高的工人死亡率略有增加（趋势P值<0.05），但这种超额死亡率主要归因于癌症死亡（趋势P值<0.01）。随着苯累积接触量的增加，淋巴和造血系统恶性肿瘤（趋势P值=0.01）及肺癌（趋势P值=0.01）导致的死亡人数增加。关于苯接触与特定淋巴和造血系统恶性肿瘤及其他死亡原因之间关系的调查仍在继续。
