Nazarenko V G
Biofizika. 1977 Sep-Oct;22(5):883-8.
A mathematical model of cell population with cooperatively controlled mitotic activity is analysed. The mitotic activity of stem cells is activated by the cells themselves and is inhibited by differentiated cells. Analysis of the model shows that steady-state oscillations in the mitotic activity are possible in such populations. The appearance of self oscillations is due to a delay in the negative feedback loop. The oscillation period, determined to a linear approximation, is greater than a quadruplicate delay.
分析了具有协同控制有丝分裂活性的细胞群体的数学模型。干细胞的有丝分裂活性由细胞自身激活，并受到分化细胞的抑制。对该模型的分析表明，在这样的群体中，有丝分裂活性的稳态振荡是可能的。自振荡的出现是由于负反馈回路中的延迟。以线性近似确定的振荡周期大于四倍延迟。
