Chen C D, Wu M Y, Yang J H, Chen S U, Ho H N, Yang Y S
Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei.
Fertil Steril. 1997 Aug;68(2):287-91. doi: 10.1016/s0015-0282(97)81517-8.
To determine the efficacy of IV albumin in the prevention of severe ovarian hyperstimulation syndrome (OHSS).
Prospective study group with historical control.
University hospital-based IVF program.
PATIENT(S): Between 1993 and 1995, 42 consecutive patients undergoing IVF-ET or tubal ET who had serum E2 levels > or = 3,600 pg/mL (conversion factor to SI unit, 3.671) on the day of hCG administration and/or > or = 20 oocytes retrieved were considered at high risk for severe OHSS and were selected as the control group. From December 1995 to October 1996, IV albumin was given to 30 consecutive patients who fulfilled these criteria.
INTERVENTION(S): The treatment group received IV albumin after oocyte retrieval.
Occurrence of severe OHSS.
RESULT(S): None of the 16 patients in the treatment group in nonconception cycles developed severe OHSS, compared with 5 (21.7%) of 23 in the control group. In conception cycles, 4 (28.6%) of 14 patients in the treatment group developed severe OHSS, compared with 9 (47.4%) of 19 in the control group. All 4 patients with multiple pregnancies in the treatment group developed severe OHSS, compared with 3 (60%) of 5 in the control group. None of the 10 patients with singleton pregnancies in the treatment group developed severe OHSS, compared with 6 (42.9%) of 14 in the control group.
CONCLUSION(S): Intravenous albumin prevents severe OHSS in high-risk patients who did not conceive or who carried singleton pregnancies, but not in the patients with high-order pregnancies.
确定静脉输注白蛋白预防严重卵巢过度刺激综合征（OHSS）的疗效。
有历史对照的前瞻性研究组。
大学医院的体外受精项目。
1993年至1995年期间，42例连续接受体外受精-胚胎移植（IVF-ET）或输卵管胚胎移植（tubal ET）的患者，在注射人绒毛膜促性腺激素（hCG）当天血清雌二醇（E2）水平≥3600 pg/mL（换算系数至国际单位制，3.671）和/或回收≥20个卵母细胞，被认为有发生严重OHSS的高风险，并被选为对照组。1995年12月至1996年10月，30例符合这些标准的连续患者接受了静脉输注白蛋白治疗。
治疗组在卵母细胞回收后接受静脉输注白蛋白。
严重OHSS的发生情况。
治疗组16例未受孕周期的患者均未发生严重OHSS，而对照组23例中有5例（21.7%）发生。在受孕周期中，治疗组14例患者中有4例（28.6%）发生严重OHSS，而对照组19例中有9例（47.4%）发生。治疗组所有4例多胎妊娠患者均发生严重OHSS，而对照组5例中有3例（60%）发生。治疗组10例单胎妊娠患者均未发生严重OHSS, 而对照组14例中有6例（42.9%）发生。
静脉输注白蛋白可预防未受孕或单胎妊娠的高风险患者发生严重OHSS，但不能预防多胎妊娠患者发生严重OHSS。
