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Evidence that PrfA, the pleiotropic activator of virulence genes in Listeria monocytogenes, can be present but inactive.有证据表明，单核细胞增生李斯特菌中毒力基因的多效激活因子PrfA可能存在但无活性。
Infect Immun. 1997 Apr;65(4):1515-8. doi: 10.1128/iai.65.4.1515-1518.1997.
2
A Gly145Ser substitution in the transcriptional activator PrfA causes constitutive overexpression of virulence factors in Listeria monocytogenes.转录激活因子PrfA中的Gly145Ser取代导致单核细胞增生李斯特菌中毒力因子的组成型过表达。
J Bacteriol. 1997 Mar;179(5):1533-40. doi: 10.1128/jb.179.5.1533-1540.1997.
3
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4
Transcriptome analysis of Listeria monocytogenes identifies three groups of genes differently regulated by PrfA.单核细胞增生李斯特菌的转录组分析鉴定出受PrfA不同调控的三组基因。
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Glucose-1-phosphate utilization by Listeria monocytogenes is PrfA dependent and coordinately expressed with virulence factors.单核细胞增生李斯特菌对葡萄糖-1-磷酸的利用依赖于PrfA，并与毒力因子协调表达。
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6
The virulence regulator protein of Listeria ivanovii is highly homologous to PrfA from Listeria monocytogenes and both belong to the Crp-Fnr family of transcription regulators.伊氏李斯特菌的毒力调节蛋白与单核细胞增生李斯特菌的PrfA高度同源，二者均属于转录调节因子的Crp - Fnr家族。
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Differential regulation of the virulence genes of Listeria monocytogenes by the transcriptional activator PrfA.转录激活因子PrfA对单核细胞增生李斯特菌毒力基因的差异调控
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Antimicrobial medium- and long-chain free fatty acids prevent PrfA-dependent activation of virulence genes in Listeria monocytogenes.抗菌中链和长链游离脂肪酸可防止单核细胞增生李斯特菌中毒力基因的PrfA依赖性激活。
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Metabolic Genetic Screens Reveal Multidimensional Regulation of Virulence Gene Expression in Listeria monocytogenes and an Aminopeptidase That Is Critical for PrfA Protein Activation.代谢遗传筛选揭示了单核细胞增生李斯特菌毒力基因表达的多维调控以及对PrfA蛋白激活至关重要的一种氨肽酶。
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本文引用的文献

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Actin-based bacterial motility: towards a definition of the minimal requirements.基于肌动蛋白的细菌运动性：迈向最小需求的定义
Trends Cell Biol. 1996 Mar;6(3):109-14. doi: 10.1016/0962-8924(96)81001-4.
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Cellular resistance to infection.细胞抗感染能力。
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Specific binding of the Listeria monocytogenes transcriptional regulator PrfA to target sequences requires additional factor(s) and is influenced by iron.单核细胞增生李斯特菌转录调节因子PrfA与靶序列的特异性结合需要其他因子，并且受铁的影响。
Mol Microbiol. 1996 Nov;22(4):643-53. doi: 10.1046/j.1365-2958.1996.d01-1722.x.
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Modulation of DNA topology by flaR, a new gene from Listeria monocytogenes.由单核细胞增生李斯特菌的一个新基因flaR对DNA拓扑结构的调控
Mol Microbiol. 1995 Dec;18(5):801-11. doi: 10.1111/j.1365-2958.1995.18050801.x.
5
A single substitution in the putative helix-turn-helix motif of the pleiotropic activator PrfA attenuates Listeria monocytogenes virulence.多效激活因子PrfA的假定螺旋-转角-螺旋基序中的单个取代会减弱单核细胞增生李斯特菌的毒力。
Mol Microbiol. 1996 May;20(4):785-97. doi: 10.1111/j.1365-2958.1996.tb02517.x.
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The catabolite repressor/activator (Cra) protein of enteric bacteria.肠道细菌的分解代谢物阻遏物/激活物（Cra）蛋白。
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Polarized distribution of Listeria monocytogenes surface protein ActA at the site of directional actin assembly.单核细胞增生李斯特菌表面蛋白ActA在肌动蛋白定向组装位点的极化分布。
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Cloning and sequencing of a cellobiose phosphotransferase system operon from Bacillus stearothermophilus XL-65-6 and functional expression in Escherichia coli.嗜热脂肪芽孢杆菌XL-65-6纤维二糖磷酸转移酶系统操纵子的克隆、测序及其在大肠杆菌中的功能表达。
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9
Regulation of the prfA transcriptional activator of Listeria monocytogenes: multiple promoter elements contribute to intracellular growth and cell-to-cell spread.单核细胞增生李斯特菌prfA转录激活因子的调控：多个启动子元件有助于细胞内生长和细胞间传播。
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10
Expression of listeriolysin and phosphatidylinositol-specific phospholipase C is repressed by the plant-derived molecule cellobiose in Listeria monocytogenes.在单核细胞增生李斯特菌中，植物来源的分子纤维二糖可抑制李斯特菌溶血素和磷脂酰肌醇特异性磷脂酶C的表达。
Mol Microbiol. 1993 May;8(4):653-61. doi: 10.1111/j.1365-2958.1993.tb01609.x.

有证据表明，单核细胞增生李斯特菌中毒力基因的多效激活因子PrfA可能存在但无活性。

Evidence that PrfA, the pleiotropic activator of virulence genes in Listeria monocytogenes, can be present but inactive.

作者信息

Renzoni A, Klarsfeld A, Dramsi S, Cossart P

机构信息

Unité des Interactions Bactéries-Cellules, Institut Pasteur, Paris, France.

出版信息

Infect Immun. 1997 Apr;65(4):1515-8. doi: 10.1128/iai.65.4.1515-1518.1997.

DOI:10.1128/iai.65.4.1515-1518.1997
PMID:9119495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC175161/
Abstract

All virulence genes of Listeria monocytogenes identified to date are positively regulated by PrfA, a transcriptional activator belonging to the Crp-Fnr family. Low temperature and cellobiose are two environmental signals known to repress expression of virulence genes in L. monocytogenes. In the present work, we analyzed the effect of temperature and cellobiose on the expression of the PrfA protein. At low temperature, PrfA was undetected, although prfA monocistronic transcripts are present. In contrast, PrfA was fully expressed in the presence of cellobiose. These results strongly suggest that virulence gene activation depends on both the presence of PrfA and additional regulatory pathways that either modify PrfA or act synergistically with PrfA.

摘要

迄今为止鉴定出的单核细胞增生李斯特菌的所有毒力基因均由PrfA正向调控，PrfA是一种属于Crp-Fnr家族的转录激活因子。低温和纤维二糖是已知可抑制单核细胞增生李斯特菌中毒力基因表达的两种环境信号。在本研究中，我们分析了温度和纤维二糖对PrfA蛋白表达的影响。在低温下，尽管存在prfA单顺反子转录本，但未检测到PrfA。相反，在纤维二糖存在的情况下，PrfA完全表达。这些结果有力地表明，毒力基因的激活既取决于PrfA的存在，也取决于其他可修饰PrfA或与PrfA协同作用的调控途径。