幽门螺杆菌对尿素、脲酶抑制剂和碳酸氢钠的不依赖脲酶的趋化反应。
Urease-independent chemotactic responses of Helicobacter pylori to urea, urease inhibitors, and sodium bicarbonate.
作者信息
Mizote T, Yoshiyama H, Nakazawa T
机构信息
Department of Microbiology, Yamaguchi University School of Medicine, Ube, Japan.
出版信息
Infect Immun. 1997 Apr;65(4):1519-21. doi: 10.1128/iai.65.4.1519-1521.1997.
Abstract
Helicobacter pylori CPY3401 and an isogenic urease-negative mutant, HPT73, showed chemotactic responses to urea, flurofamide (a potent urease inhibitor), and sodium bicarbonate. Since urea and sodium bicarbonate are secreted through the gastric epithelial surface and hydrolysis of urea by urease on the bacterial surface is essential for colonization, the chemotactic response of H. pylori may be crucial for its colonization and persistence in the stomach.
摘要
幽门螺杆菌CPY3401及其同基因脲酶阴性突变体HPT73对尿素、氟甲酰胺（一种有效的脲酶抑制剂）和碳酸氢钠表现出趋化反应。由于尿素和碳酸氢钠是通过胃上皮表面分泌的，并且细菌表面脲酶对尿素的水解对于定植至关重要，因此幽门螺杆菌的趋化反应可能对其在胃中的定植和持续存在至关重要。
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