Lima de Souza Gonçalves Vinícius, Cordeiro Santos Maria Luísa, Silva Luz Marcel, Santos Marques Hanna, de Brito Breno Bittencourt, França da Silva Filipe Antônio, Souza Cláudio Lima, Oliveira Márcio Vasconcelos, de Melo Fabrício Freire
Universidade Estadual do Sudoeste da Bahia, Campus Vitória da Conquista, Vitória da Conquista 45083-900, Bahia, Brazil.
Universidade Federal da Bahia, Instituto Multidisciplinar em Saúde, Vitória da Conquista 45029-094, Bahia, Brazil.
World J Clin Oncol. 2022 Mar 24;13(3):186-199. doi: 10.5306/wjco.v13.i3.186.
Gastric cancer (GC) is the result of a multifactorial process whose main components are infection by (), bacterial virulence factors, host immune response and environmental factors. The development of the neoplastic microenvironment also depends on genetic and epigenetic changes in oncogenes and tumor suppressor genes, which results in deregulation of cell signaling pathways and apoptosis process. This review summarizes the main aspects of the pathogenesis of GC and the immune response involved in chronic inflammation generated by .
胃癌（GC）是一个多因素过程的结果，其主要组成部分是（）感染、细菌毒力因子、宿主免疫反应和环境因素。肿瘤微环境的发展还取决于癌基因和肿瘤抑制基因的遗传和表观遗传变化，这导致细胞信号通路和凋亡过程失调。本综述总结了GC发病机制的主要方面以及由（）产生的慢性炎症中涉及的免疫反应。
