Gillaspy A F, Patti J M, Smeltzer M S
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
Infect Immun. 1997 Apr;65(4):1536-40. doi: 10.1128/iai.65.4.1536-1540.1997.
We demonstrate that transcription of the Staphylococcus aureus collagen adhesin gene (cna) is temporally regulated, with expression being highest in exponentially growing cultures and falling to almost undetectable levels as cultures enter the post-exponential-growth phase. The temporal regulation of cna transcription was not affected by mutation of agr. We also demonstrate that the collagen adhesin is expressed by both agr+ and agr-negative S. aureus cells growing in bone.
我们证明，金黄色葡萄球菌胶原黏附素基因（cna）的转录受时间调控，在指数生长期的培养物中表达最高，而当培养物进入指数生长后期时，表达水平降至几乎检测不到。cna转录的时间调控不受agr突变的影响。我们还证明，在骨中生长的agr+和agr阴性金黄色葡萄球菌细胞均表达胶原黏附素。
