Afanas'eva G A, Zalitis G M, Chipens G I
Biokhimiia. 1977 Sep;42(9):1720-6.
The antigenic activity of angiotensin and its seven fragments has been studied in cross-reaction with specific antibodies, elicited to angiotensin and its fragments: C-terminal hexapeptide and middle tetrapeptide. It has been found that all the fragments studied possess certain affinity for antibodies elicited to angiotensin, C-terminal hexapeptide and middle tetrapeptide. The middle tetrapeptide was identified to be the immunologically active centre of the angiotensin molecule.
已对血管紧张素及其七个片段的抗原活性进行了研究,研究内容为它们与针对血管紧张素及其片段(C端六肽和中间四肽)产生的特异性抗体的交叉反应。研究发现,所有研究的片段对针对血管紧张素、C端六肽和中间四肽产生的抗体都具有一定亲和力。已确定中间四肽是血管紧张素分子的免疫活性中心。