Fellström B, Backman U, Danielson B G, Johansson G, Ljunghall S, Wikström B
J Urol. 1982 Mar;127(3):589-92. doi: 10.1016/s0022-5347(17)53918-x.
The 24-hour urinary excretion of urate was investigated in 467 consecutive stone formers - 350 males and 117 females - and 89 apparently healthy controls with no history of stone disease. Males had a higher urinary excretion of urate than females but there was no difference between stone formers and controls. Urinary urate decreased with advancing age. Patients with a proximal tubular acidification defect had a lower urate clearance than patients with a normal acidification of the urine. Patients with hyperuricosuria presented a higher frequency of stone operations but a lower stone episode rate than matched normouricosuric stone formers. Hyperuricosuria in combination with renal acidification defects was associated with the highest frequency of stone operations. Hyperuricosuric patients also had a higher excretion of calcium than normouricosuric patients. Hyperuricosuria is not a common feature of calcium stone disease but when present is associated with a more severe stone disease in terms of stone operations.
对467例连续性结石患者（350例男性和117例女性）以及89例无结石病史的明显健康对照者进行了24小时尿酸排泄情况的研究。男性的尿酸尿排泄量高于女性，但结石患者与对照者之间无差异。尿酸尿排泄量随年龄增长而降低。近端肾小管酸化缺陷患者的尿酸清除率低于尿液酸化正常的患者。高尿酸尿症患者的结石手术频率较高，但与匹配的正常尿酸尿症结石患者相比，结石发作率较低。高尿酸尿症合并肾脏酸化缺陷与最高的结石手术频率相关。高尿酸尿症患者的钙排泄量也高于正常尿酸尿症患者。高尿酸尿症不是钙结石病的常见特征，但一旦出现，就结石手术而言，与更严重的结石病相关。
