Jetschmann J U, Benschop R J, Jacobs R, Kemper A, Oberbeck R, Schmidt R E, Schedlowski M
Division of Clinical Immunology, Hannover Medical School, Germany.
J Neuroimmunol. 1997 Apr;74(1-2):159-64. doi: 10.1016/s0165-5728(96)00221-4.
Expression and in-vivo modulation of beta- and alpha-adrenoceptors on peripheral human natural killer (CD16+) cells was investigated. Ligand binding studies revealed that CD16+ lymphocytes express beta2, alpha1-, alpha2- but not beta1-adrenoceptors. Infusion of adrenaline, but not noradrenaline, significantly decreased beta2- and alpha1-adrenoceptor numbers on NK cells. Both catecholamines did not appreciably alter alpha2-adrenoceptor numbers. Additional analyses showed that adrenaline administration increases alpha2-adrenoceptor numbers on peripheral mononuclear blood cells (PBMC) and T-cell subsets (CD4+, CD8+) in contrast to decreased receptor numbers on CD16+ cells. These data demonstrate a specific effect of increasing levels of circulating catecholamines on beta2-adrenoceptors on NK cells.
研究了外周血人类自然杀伤（CD16 +）细胞上β和α肾上腺素能受体的表达及体内调节。配体结合研究表明，CD16 +淋巴细胞表达β2、α1、α2肾上腺素能受体，但不表达β1肾上腺素能受体。输注肾上腺素而非去甲肾上腺素可显著降低NK细胞上β2和α1肾上腺素能受体的数量。两种儿茶酚胺均未明显改变α2肾上腺素能受体的数量。进一步分析表明，与CD16 +细胞上受体数量减少相反，给予肾上腺素可增加外周血单个核细胞（PBMC）和T细胞亚群（CD4 +、CD8 +）上α2肾上腺素能受体的数量。这些数据证明了循环儿茶酚胺水平升高对NK细胞上β2肾上腺素能受体具有特定作用。
