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Platelet GPIIb/IIIa antagonists: the first anti-integrin receptor therapeutics.

作者信息

Coller B S

机构信息

Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

出版信息

J Clin Invest. 1997 Apr 1;99(7):1467-71. doi: 10.1172/JCI119307.

DOI:10.1172/JCI119307
PMID:9119988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC507964/
Abstract
摘要

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本文引用的文献

1
In vitro effects of the platelet glycoprotein IIb/IIIa receptor antagonist c7E3 Fab on the activated clotting time.血小板糖蛋白IIb/IIIa受体拮抗剂c7E3 Fab对活化凝血时间的体外作用。
Circulation. 1997 Feb 4;95(3):614-7. doi: 10.1161/01.cir.95.3.614.
2
In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors VIIa and X.通过地高辛标记的因子VIIa和X的结合对人动脉粥样硬化斑块中组织因子进行原位定位。
Lab Invest. 1996 Oct;75(4):451-61.
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Adhesion of platelets to surface-bound fibrinogen under flow.流动状态下血小板与表面结合的纤维蛋白原的黏附。
Blood. 1996 Oct 15;88(8):2967-72.
4
Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18.中性粒细胞通过P-选择素和β2整合素CD11b/CD18的相继作用，在活化的、表面黏附的血小板上滚动、黏附并迁移。
Blood. 1996 Jul 1;88(1):146-57.
5
Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and "clinical restenosis".小鼠/人嵌合7E3抗体对血小板介导的、组织因子诱导的凝血酶生成的抑制作用。对c7E3 Fab治疗急性血栓形成和“临床再狭窄”效果的潜在影响。
J Clin Invest. 1996 Aug 1;98(3):863-74. doi: 10.1172/JCI118859.
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Thrombosis and inflammation as multicellular processes: significance of cell-cell interactions.
Thromb Haemost. 1995 Jul;74(1):213-7.
7
Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor.通过黏附于纤维蛋白原或在血管性血友病因子上移位来启动血小板黏附。
Cell. 1996 Jan 26;84(2):289-97. doi: 10.1016/s0092-8674(00)80983-6.
8
Studies of activated GPIIb/IIIa receptors on the luminal surface of adherent platelets. Paradoxical loss of luminal receptors when platelets adhere to high density fibrinogen.对黏附血小板腔表面活化的糖蛋白IIb/IIIa受体的研究。当血小板黏附于高密度纤维蛋白原时，腔表面受体出现矛盾性丢失。
J Clin Invest. 1993 Dec;92(6):2796-806. doi: 10.1172/JCI116899.
9
Pharmacokinetics and pharmacodynamics of MK-383, a selective non-peptide platelet glycoprotein-IIb/IIIa receptor antagonist, in healthy men.
Clin Pharmacol Ther. 1994 Oct;56(4):377-88. doi: 10.1038/clpt.1994.152.
10
Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation.
Circulation. 1994 Nov;90(5):2203-6. doi: 10.1161/01.cir.90.5.2203.