Srinivasan R, Dean H A
Texas Tech University Health Sciences Center, Amarillo 79106-1797, USA.
J Toxicol Clin Toxicol. 1997;35(2):199-202. doi: 10.3109/15563659709001194.
Thorotrast, a radiological contrast medium that was widely used from 1928-1955 is a thorium dioxide colloid that has been neutralized and stabilized by colloid, composed of dextran. The major site of deposition is the reticuloendothelial system where it is retained for a long time.
Complications occurring late after exposure to thorotrast are described in two patients.
One patient had angiosarcoma of liver metastatic to bone and bone marrow failure after a 43 year latency period. The other patient had a thorotrast granuloma and angiosarcoma of the liver after 22 year and 28 year latency periods respectively.
Complications due to thorotrast appear to represent consequences of chronic alpha irradiation.
钍造影剂是一种在1928年至1955年被广泛使用的放射造影剂，它是一种经葡聚糖胶体中和并稳定化的二氧化钍胶体。其主要沉积部位是网状内皮系统，在该系统中它会长期留存。
描述了两名接触钍造影剂后出现晚期并发症的患者。
一名患者在接触钍造影剂43年后发生了肝血管肉瘤转移至骨以及骨髓衰竭。另一名患者分别在接触钍造影剂22年和28年后发生了钍造影剂肉芽肿和肝血管肉瘤。
钍造影剂所致并发症似乎是慢性α射线照射的后果。
