Singhai A K, Jain S, Jain N K
Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar (M.P.) India.
Pharmazie. 1997 Feb;52(2):149-51.
The increase in aqueous solubility of ketoprofen using hydrotropes and cosolvents in formulation, as well as stability studies of its aqueous injections have been reported earlier. These formulations were further evaluated in vitro (physical evaluation, haemolytic activity) and in vivo (pharmacokinetic studies). Some of the formulations have shown promising results.
此前已有报道称，在制剂中使用助溶剂和共溶剂可提高酮洛芬的水溶性，以及其水针剂的稳定性研究。这些制剂进一步进行了体外（物理评价、溶血活性）和体内（药代动力学研究）评估。一些制剂已显示出有前景的结果。
