Hallson P C, Rose G A
Br J Urol. 1977 Aug;49(4):277-84. doi: 10.1111/j.1464-410x.1977.tb04137.x.
Individual urine samples from normal subjects and stone-formers with idiopathic hypercalciuria have been examined for crystals both qualitatively and quantitatively at 37 degrees C. The group as a whole showed a rise in incidence of urinary crystals in the summer months of June to August inclusive. This rise was seen most clearly in overnight urines, collected on rising in the morning, and the patients appeared to be at risk overnight during the summer. In the untreated patients the summer rise in incidence of phosphate crystals was quite dramatic but was only small in the cellulose phosphate treated group, who showed a rather constant and raised incidence of oxalate crystals right through the year. Seasonal crystal incidence has been compared with seasonal changes in urinary composition. The rise in crystal incidence during the summer was associated with increased creatinine concentration in the same urine samples and with increased oxalate concentration in 24-hour urine collections.
对正常受试者以及患有特发性高钙尿症的结石形成者的个体尿液样本，在37摄氏度下进行了晶体的定性和定量检测。总体而言，该组人群在6月至8月（含）的夏季月份中，尿结晶的发生率有所上升。这种上升在清晨起床后收集的晨尿中最为明显，患者在夏季夜间似乎处于风险之中。在未经治疗的患者中，夏季磷酸盐晶体发生率的上升相当显著，但在接受磷酸纤维素治疗的组中则较小，该组全年草酸钙晶体的发生率相当恒定且有所升高。已将季节性晶体发生率与尿液成分的季节性变化进行了比较。夏季晶体发生率的上升与相同尿液样本中肌酐浓度的增加以及24小时尿液收集物中草酸盐浓度的增加有关。
