Hallson P C, Kasidas G P, Rose G A
Urol Res. 1976;4(4):169-73. doi: 10.1007/BF00262350.
Urinary oxalate excretion has been measured by a specific enzymatic method in normal subjects and stone formers with idiopathic hypercalciuria. In every group studied urinary oxalate was higher in the summer than in the winter. These differences were slight and not significant in normal subjects but were considerable and statistically significant in the stone formers both untreated and when treated with thiazide. Thiazides raise urinary oxalate only very slightly but cellulose phosphate leads to large rises in urinary oxalate both in the summer and the winter. The highest values of urinary oxalate were seen in the summer in patients treated with cellulose phosphate. The mean rise in this group was 70% above normal and this must be viewed with some anxiety.
已通过特定酶法对正常受试者以及患有特发性高钙尿症的结石形成者的尿草酸排泄量进行了测定。在每个研究组中，夏季的尿草酸水平均高于冬季。这些差异在正常受试者中较小且无统计学意义，但在未经治疗以及接受噻嗪类药物治疗的结石形成者中差异显著且具有统计学意义。噻嗪类药物仅使尿草酸略有升高，但纤维素磷酸盐在夏季和冬季都会导致尿草酸大幅升高。接受纤维素磷酸盐治疗的患者在夏季尿草酸水平最高。该组的平均升高幅度比正常水平高70%，对此必须予以一定程度的关注。
