Hallson P C, Rose G A
Br J Urol. 1976;48(7):515-24. doi: 10.1111/j.1464-410x.1976.tb06696.x.
Quantitative and qualitative studies have been made of the urinary crystals from a series of normal subjects and from stone formers with idiopathic hypercalciuria with and without treatment with thiazide diuretics and/or cellulose phosphate. The results obtained from mid-morning unprepared subjects seemed more helpful than those obtained following overnight collections or after a dry breakfast. Crystalluria was more common in stone formers than in normal subjects, but was seen in both groups. The most striking difference between these 2 groups was the almost complete absence of aggregation of oxalate crystals in the normal subjects. Cellulose phosphate greatly reduced phosphate crystals but resulted in a large increase in small oxalate crystals but without change in the incidence of aggregation of oxalate crystals. Thiazides also reduced occurrence of phosphate crystals but only gave a very small increase in oxalate crystals and also without change in aggregation of oxalate crystals.
对一系列正常受试者以及患有特发性高钙尿症的结石形成者（无论是否接受噻嗪类利尿剂和/或磷酸纤维素治疗）的尿结晶进行了定量和定性研究。从上午中段未做准备的受试者获得的结果似乎比过夜收集或干早餐后获得的结果更有帮助。结晶尿在结石形成者中比在正常受试者中更常见，但在两组中均可见到。这两组之间最显著的差异是正常受试者中草酸盐晶体几乎完全没有聚集。磷酸纤维素大大减少了磷酸盐晶体，但导致小的草酸盐晶体大量增加，但草酸盐晶体聚集的发生率没有变化。噻嗪类药物也减少了磷酸盐晶体的出现，但仅使草酸盐晶体略有增加，草酸盐晶体的聚集也没有变化。
