绝经后女性雌激素与钙的前瞻性试验。
Prospective trial of oestrogen and calcium in postmenopausal women.
作者信息
Horsman A, Gallagher J C, Simpson M, Nordin B E
出版信息
Br Med J. 1977 Sep 24;2(6090):789-92. doi: 10.1136/bmj.2.6090.789.
In a prospective trial in 72 postmenopausal women to compare the effects on bone loss of no treatment, treatment with oestrogen, and treatment with calcium the women were followed up for at least two years and examined densitometrically and morphometrically. Women in the untreated control group continued to lose bone during the two years, whereas the oestrogen-treated group lost none. Loss in the calcium-treated group was intermediate. Oestrogen appeared to inhibit endosteal bone resorption and may have stimulated subperiosteal bone apposition.
在一项针对72名绝经后女性的前瞻性试验中，为比较不治疗、雌激素治疗和钙治疗对骨质流失的影响，对这些女性进行了至少两年的随访，并进行了骨密度测量和形态测量。未治疗的对照组女性在两年中持续骨质流失，而接受雌激素治疗的组没有骨质流失。接受钙治疗的组骨质流失情况介于两者之间。雌激素似乎抑制了骨内膜的骨吸收，并且可能刺激了骨膜下的骨沉积。
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