McOrist S, Smith S H, Shearn M F, Carr M M, Miller D J
Department of Veterinary Pathology, University of Edinburgh, Easter Bush, Midlothian.
Vet Rec. 1996;139(25):615-8.
The effect of an oral treatment or prevention programme, incorporating the antibiotic tiamulin, on the development of proliferative enteropathy in experimentally challenged pigs was studied. Twenty weaner pigs were challenged orally with a virulent inoculum of Lawsonia intracellularis strain LR189/5/83, a British isolate of the causative agent of porcine proliferative enteropathy, and seven control pigs were dosed with a buffer solution. Seven of the 20 challenged pigs were left untreated; they gained less weight than the controls and three of them developed mild to moderate diarrhoea two weeks after the challenge. All seven developed lesions, six visible grossly, of proliferative enteropathy, and numerous intracellular L intracellularis were detected in sections of the intestines examined three weeks after the challenge. To test a 'prevention' dosing strategy for tiamulin, six of the challenged pigs were dosed orally with 50 ppm tiamulin, incorporated in a 2 per cent stabilised premix, given from two days before the challenge until they were euthanased. To test a 'treatment' strategy, the remaining group of seven challenged pigs were dosed orally with 150 ppm tiamulin given in the premix from seven days after challenge until they were euthanased. All the control pigs and the 13 pigs treated with tiamulin, either before or after challenge, remained clinically normal and had no specific lesions of proliferative enteropathy in sections of the intestines examined post mortem.
研究了一种包含抗生素泰妙菌素的口服治疗或预防方案对实验性攻毒猪增生性肠炎发展的影响。20头断奶仔猪经口接种猪增生性肠炎病原体的强毒株劳森菌LR189/5/83（一种英国分离株），7头对照猪给予缓冲溶液。20头攻毒猪中有7头未接受治疗；它们的体重增长低于对照组，其中3头在攻毒两周后出现轻度至中度腹泻。所有7头猪均出现增生性肠炎病变，6头肉眼可见，攻毒三周后检查的肠道切片中检测到大量胞内劳森菌。为测试泰妙菌素的“预防”给药策略，6头攻毒猪从攻毒前两天开始至处死前口服含50 ppm泰妙菌素的2%稳定预混料。为测试“治疗”策略，其余7头攻毒猪从攻毒七天后开始至处死前口服含150 ppm泰妙菌素的预混料。所有对照猪以及13头在攻毒前后接受泰妙菌素治疗的猪在临床上均保持正常，死后检查的肠道切片中无增生性肠炎的特异性病变。
