Chengappa M M, Pace L W, Williams J A, Herren C H, Ascher S E
Breathitt Veterinary Center, Murray State University, Hopkinsville, KY 42240.
J Am Vet Med Assoc. 1990 Dec 1;197(11):1467-70.
Eighteen 4-week-old pigs were used in a study to evaluate tiamulin in drinking water for control of experimentally induced Streptococcus suis type-2 infection. Pigs in groups A and B (n = 6 pigs/group) were aerosolized with a logarithmic-growth phase culture of S suis type 2, whereas pigs in group C (n = 6 pigs) served as noninfected and nonmedicated controls. After exposure to S suis, pigs in group B were given 180 mg of tiamulin/L of drinking water for 5 days. Pigs in group B consumed more feed (P = 0.009) and gained body weight faster (P = 0.02) than did pigs in group A. Pigs in group A had higher rectal temperature (P = 0.05) for up to 7 days after S suis exposure, higher clinical sign scores (P = 0.008), higher serum cortisol concentration on days 7 and 14, higher gross lesion scores (P = 0.03), and higher microscopic lesion scores (P = 0.01) than did pigs in groups B and C. Gross and microscopic lesions in pigs of groups A and B included meningitis, pneumonia, pleuritis, pericarditis, peritonitis, and synovitis of variable severity. Streptococcus suis type 2 was recovered from tissue specimens of 2 group-A pigs and 1 group-B pig. Data indicated that tiamulin administered via drinking water significantly reduced the effects of S suis type-2 infection.
一项研究使用了18头4周龄的猪来评估饮水添加泰妙菌素对实验性诱导的2型猪链球菌感染的控制效果。A组和B组的猪（每组6头猪）用2型猪链球菌的对数生长期培养物进行雾化，而C组的猪（6头猪）作为未感染且未用药的对照。接触2型猪链球菌后，B组的猪饮用含180 mg泰妙菌素/L的水，持续5天。B组的猪比A组的猪消耗更多饲料（P = 0.009），体重增加更快（P = 0.02）。A组的猪在接触2型猪链球菌后的7天内直肠温度更高（P = 0.05），临床症状评分更高（P = 0.008），第7天和第14天血清皮质醇浓度更高，大体病变评分更高（P = 0.03），显微镜下病变评分更高（P = 0.01），高于B组和C组的猪。A组和B组猪的大体和显微镜下病变包括不同严重程度的脑膜炎、肺炎、胸膜炎、心包炎、腹膜炎和滑膜炎。从2头A组猪和1头B组猪的组织标本中分离出了2型猪链球菌。数据表明，通过饮水给予泰妙菌素可显著降低2型猪链球菌感染的影响。
