铊中毒对大鼠下丘脑和海马体的电子显微镜观察结果：大脑中的生化变化
Electron microscopic effects of thallium poisoning on the rat hypothalamus and hippocampus: biochemica changes in the cerebrum.
作者信息
Hasan M, Chandra S V, Bajpai V K, Ali S F
出版信息
Brain Res Bull. 1977 Jul-Aug;2(4):255-61. doi: 10.1016/0361-9230(77)90081-8.
PMID:912438
Abstract
Rats were given thallous acetate (5 mg elemental thallium/kg body weight) IP daily for 7 days and prepared for electron microscopy (perfusion-fixation) and for biochemical study. Increased incidence of Golgi zones and electron-dense bodies were observed in the anterior hypothalamus and hippocampus. Sequestrated axons were seen in the hypothalamus. Depletion of succinic dehydrogenase and guanine deaminase occurred in the cerebrum.
摘要
给大鼠腹腔注射醋酸铊（5毫克元素铊/千克体重），每日一次，持续7天，然后为进行电子显微镜检查（灌注固定）和生化研究做准备。在前下丘脑和海马体中观察到高尔基体区域和电子致密体的发生率增加。在下丘脑中可见隔离的轴突。大脑中琥珀酸脱氢酶和鸟嘌呤脱氨酶减少。
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