Deshimaru M, Miyakawa T, Sumiyoshi S, Yasuoka F, Kawano K
Folia Psychiatr Neurol Jpn. 1977;31(2):269-75. doi: 10.1111/j.1440-1819.1977.tb02728.x.
To adult male rats 2 mg per rat of thallium acetate: CH3 COOT1 was given orally daily for six months. Clinically, the experimental rats revealed only alopecia and showed no neurological signs. Pathological findings were noted in muscle and cerebrum. Marked changes were observed in muscles and were as follows: swelling and vacuolation of mitochondria, destruction of cristae, ruptures of mitochondrial membranes, degeneration of sarcoplasmic reticulum and destruction of myofilaments. In the cerebrum, there were vacuolation of mitochondria, dilatation of Golgi cisterns in hypothalamus and thalamus. Sciatic nerve, liver and kidney were intact. From this, we consider that T1+ ions selectively affect the muscle and its mitochondria.
给成年雄性大鼠每日经口给予每只大鼠2毫克醋酸铊（CH3COOTl），持续6个月。临床上，实验大鼠仅出现脱发，未表现出神经症状。在肌肉和大脑中观察到病理变化。在肌肉中观察到明显变化，如下所示：线粒体肿胀和空泡化、嵴破坏、线粒体膜破裂、肌浆网变性和肌丝破坏。在大脑中，有线粒体空泡化、下丘脑和丘脑的高尔基池扩张。坐骨神经、肝脏和肾脏未受影响。由此，我们认为Tl +离子选择性地影响肌肉及其线粒体。
