VanTeeffelen J W, Merkus D, Vergroesen I, Spaan J A
Department of Medical Physics, Academic Medical Center, University of Amsterdam, The Netherlands.
Am J Physiol. 1997 Feb;272(2 Pt 2):H706-13. doi: 10.1152/ajpheart.1997.272.2.H706.
The effect of increased fluid filtration on stopped-flow epicardial lymph pressure (P(lymph)), used as an indicator of myocardial interstitial volume, was investigated in the anesthetized open-chest dog. Histamine infusion resulted in an increased systolic peak in the P(lymph) signal together with an increase in diastolic P(lymph) in four of five animals. During reactive hyperemia, systolic and diastolic P(lymph) increased to 127 +/- 8 and 121 +/- 6.7% (mean +/- SE, n = 6) of control, respectively. Peak P(lymph) was approximately 15 s later than peak coronary blood flow and venous pressure (P(ven)). When P(ven) was transiently elevated to 367 +/- 72 (systolic) and 247 +/- 45% (diastolic) of control, P(lymph) increased to 132 +/- 12 and 120 +/- 5.5% of control. The time of response was similar for P(ven) and P(lymph) (t50 approximately 2 S). The increased systolic and diastolic P(lymph) can be explained by an increase in interstitial and lymph filling. It is concluded that changes in myocardial fluid filtration are reflected in epicardial P(lymph). Furthermore, it seems that cardiac contraction constitutes an important defense mechanism against the formation of myocardial edema.
在麻醉开胸犬中，研究了增加液体滤过对用作心肌间质容积指标的停流心外膜淋巴压力（P(lymph)）的影响。在五只动物中的四只中，输注组胺导致P(lymph)信号的收缩期峰值增加以及舒张期P(lymph)升高。在反应性充血期间，收缩期和舒张期P(lymph)分别增加至对照值的127±8%和121±6.7%（平均值±标准误，n = 6）。P(lymph)峰值比冠状动脉血流峰值和静脉压力（P(ven)）峰值晚约15秒。当P(ven)短暂升高至对照值的367±72%（收缩期）和247±45%（舒张期）时，P(lymph)增加至对照值的132±12%和120±5.5%。P(ven)和P(lymph)的反应时间相似（t50约为2秒）。收缩期和舒张期P(lymph)的增加可以用间质和淋巴充盈增加来解释。结论是，心肌液体滤过的变化反映在心外膜P(lymph)中。此外，心脏收缩似乎构成了防止心肌水肿形成的重要防御机制。
