Mo Z, Luo J, Li M
Department of Applied Chemistry, Sichuan Union University, Chengdu, China.
Analyst. 1997 Feb;122(2):111-3. doi: 10.1039/a605796i.
A rapid and simple method for the determination of lignocaine hydrochloride by ion-pairing flow injection analysis was developed. It is based on the formation of an ion pair between lignocaine hydrochloride and sodium dodecyl phenylsulfonate and piezoelectric detection. The calibration curve was linear between 0.01 and 2.00 mg ml-1, with a detection limit of 8 micrograms ml-1, an RSD of 0.29% (10 replicates) and a sampling frequency of 120 h-1. The proposed method was satisfactorily applied to the determination of lignocaine hydrochloride in pharmaceutical preparations.
建立了一种快速简便的离子对流动注射分析法测定盐酸利多卡因的方法。该方法基于盐酸利多卡因与十二烷基苯磺酸钠形成离子对并采用压电检测。校准曲线在0.01至2.00 mg ml-1之间呈线性，检测限为8微克ml-1，相对标准偏差为0.29%（10次重复），进样频率为120 h-1。该方法成功应用于药物制剂中盐酸利多卡因的测定。
