• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Comparative serum bactericidal activities of ceftizoxime and cefotaxime against intermediately penicillin-resistant Streptococcus pneumoniae.头孢唑肟和头孢噻肟对中度耐青霉素肺炎链球菌的血清杀菌活性比较
Antimicrob Agents Chemother. 1996 Dec;40(12):2805-8. doi: 10.1128/AAC.40.12.2805.
2
Pharmacodynamic effects of amoxicillin versus cefotaxime against penicillin-susceptible and penicillin-resistant pneumococcal strains: a phase I study.阿莫西林与头孢噻肟对青霉素敏感和青霉素耐药肺炎球菌菌株的药效学作用：一项I期研究。
Antimicrob Agents Chemother. 1997 Jun;41(6):1389-91. doi: 10.1128/AAC.41.6.1389.
3
Comparative study of pharmacokinetics and serum bactericidal activity of ceftizoxime and cefotaxime.头孢唑肟与头孢噻肟的药代动力学及血清杀菌活性的对比研究
Antimicrob Agents Chemother. 1991 Oct;35(10):2057-64. doi: 10.1128/AAC.35.10.2057.
4
In vitro killing of penicillin-susceptible, -intermediate, and -resistant strains of Streptococcus pneumoniae by cefotaxime, ceftriaxone, and ceftizoxime: a comparison of bactericidal and inhibitory activity with achievable CSF levels.头孢噻肟、头孢曲松和头孢唑肟对青霉素敏感、中介及耐药肺炎链球菌菌株的体外杀伤作用：杀菌和抑菌活性与脑脊液可达到水平的比较
Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):35-42. doi: 10.1016/0732-8893(95)00094-q.
5
Efficacies of cefotaxime and ceftriaxone in a mouse model of pneumonia induced by two penicillin- and cephalosporin-resistant strains of Streptococcus pneumoniae.头孢噻肟和头孢曲松在两种对青霉素和头孢菌素耐药的肺炎链球菌菌株诱导的小鼠肺炎模型中的疗效。
Antimicrob Agents Chemother. 1996 Dec;40(12):2829-34. doi: 10.1128/AAC.40.12.2829.
6
Activity of penicillin and three third-generation cephalosporins against US isolates of Streptococcus pneumoniae: a 1995 surveillance study.青霉素及三种第三代头孢菌素对美国肺炎链球菌分离株的活性：一项1995年的监测研究
Diagn Microbiol Infect Dis. 1996 Jun;25(2):89-95. doi: 10.1016/s0732-8893(96)00098-3.
7
Diminished activity of ceftizoxime in comparison to cefotaxime and ceftriaxone against Streptococcus pneumoniae.与头孢噻肟和头孢曲松相比，头孢唑肟对肺炎链球菌的活性降低。
Clin Infect Dis. 1995 Mar;20(3):671-6. doi: 10.1093/clinids/20.3.671.
8
Serum bactericidal activity of ceftizoxime and ceftriaxone against pathogens associated with community-acquired and nosocomial pneumonias.
Am J Health Syst Pharm. 1996 May 1;53(9):1024-7. doi: 10.1093/ajhp/53.9.1024.
9
Choice of an oral beta-lactam antibiotic for infections due to penicillin-resistant Streptococcus pneumoniae.用于治疗耐青霉素肺炎链球菌感染的口服β-内酰胺类抗生素的选择。
Scand J Infect Dis. 1997;29(3):255-7. doi: 10.3109/00365549709019038.
10
Predicting susceptibility of Streptococcus pneumoniae to ceftriaxone and cefotaxime by cefuroxime and ceftizoxime disk diffusion testing.通过头孢呋辛和头孢唑肟纸片扩散试验预测肺炎链球菌对头孢曲松和头孢噻肟的敏感性。
J Clin Microbiol. 1999 Nov;37(11):3707-10. doi: 10.1128/JCM.37.11.3707-3710.1999.

引用本文的文献

1
Physicochemical Characteristics of Antimicrobials and Practical Recommendations for Intravenous Administration: A Systematic Review.抗菌药物的物理化学特性及静脉给药实用建议：一项系统评价
Antibiotics (Basel). 2023 Aug 19;12(8):1338. doi: 10.3390/antibiotics12081338.
2
Bactericidal activities of ceftizoxime and cefotaxime against Streptococcus pneumoniae.头孢唑肟和头孢噻肟对肺炎链球菌的杀菌活性。
Antimicrob Agents Chemother. 1998 Jul;42(7):1869-70. doi: 10.1128/AAC.42.7.1869.

本文引用的文献

1
Drug-resistant pneumococcal infections in the United States. A problem for clinicians, laboratories, and public health.美国的耐药肺炎球菌感染。这是临床医生、实验室和公共卫生领域面临的一个问题。
JAMA. 1994 Jun 15;271(23):1875-6.
2
Diminished activity of ceftizoxime in comparison to cefotaxime and ceftriaxone against Streptococcus pneumoniae.与头孢噻肟和头孢曲松相比，头孢唑肟对肺炎链球菌的活性降低。
Clin Infect Dis. 1995 Mar;20(3):671-6. doi: 10.1093/clinids/20.3.671.
3
Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins.在确定广谱头孢菌素给药方案时药代动力学与药效学之间的相互关系。
Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):89-96. doi: 10.1016/0732-8893(95)00053-d.
4
In vitro killing of penicillin-susceptible, -intermediate, and -resistant strains of Streptococcus pneumoniae by cefotaxime, ceftriaxone, and ceftizoxime: a comparison of bactericidal and inhibitory activity with achievable CSF levels.头孢噻肟、头孢曲松和头孢唑肟对青霉素敏感、中介及耐药肺炎链球菌菌株的体外杀伤作用：杀菌和抑菌活性与脑脊液可达到水平的比较
Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):35-42. doi: 10.1016/0732-8893(95)00094-q.
5
Experimental Streptococcus pneumoniae infection in mice for studying correlation of in vitro and in vivo activities of penicillin against pneumococci with various susceptibilities to penicillin.通过在小鼠身上进行肺炎链球菌感染实验，以研究青霉素对不同青霉素敏感性肺炎球菌的体外和体内活性之间的相关性。
Antimicrob Agents Chemother. 1995 Jun;39(6):1253-8. doi: 10.1128/AAC.39.6.1253.
6
Cefotaxime. A review of its antibacterial activity, pharmacological properties and therapeutic use.头孢噻肟：抗菌活性、药理特性及治疗用途综述
Drugs. 1983 Mar;25(3):223-89. doi: 10.2165/00003495-198325030-00001.
7
Comparative study of pharmacokinetics and serum bactericidal activity of ceftizoxime and cefotaxime.头孢唑肟与头孢噻肟的药代动力学及血清杀菌活性的对比研究
Antimicrob Agents Chemother. 1991 Oct;35(10):2057-64. doi: 10.1128/AAC.35.10.2057.

头孢唑肟和头孢噻肟对中度耐青霉素肺炎链球菌的血清杀菌活性比较

Comparative serum bactericidal activities of ceftizoxime and cefotaxime against intermediately penicillin-resistant Streptococcus pneumoniae.

作者信息

Patel K B, Nicolau D P, Nightingale C H, Quintiliani R

机构信息

Department of Pharmacy Practice, Arnold and Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, New York 11201, USA.

出版信息

Antimicrob Agents Chemother. 1996 Dec;40(12):2805-8. doi: 10.1128/AAC.40.12.2805.

DOI:10.1128/AAC.40.12.2805
PMID:9124845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163626/
Abstract

In a randomized crossover study involving 12 healthy volunteers, 1 g of ceftizoxime or cefotaxime was administered intravenously every 12 h for a total of three doses on two separate weekends. The duration of serum bactericidal titers (SBTs) greater than 1:2 and the time serum drug concentrations remained above the MIC (T > MIC) were determined against three clinical isolates of Streptococcus pneumoniae with intermediate resistance to penicillin. The duration of SBTs and T > MIC for both antimicrobial agents exceeded 50% of the dosing interval for all isolates. Ceftizoxime's T > MIC was statistically greater than that of cefotaxime, indicating that its longer half-life in serum (1.7 h) compared with that of cefotaxime (approximately 1 h) compensates for its slightly lower microbiologic activity against the penicillin-resistant pneumococci tested in this study.

摘要

在一项涉及12名健康志愿者的随机交叉研究中，在两个不同的周末，每12小时静脉注射1克头孢唑肟或头孢噻肟，共注射三剂。针对三株对青霉素具有中度耐药性的肺炎链球菌临床分离株，测定血清杀菌效价（SBT）大于1:2的持续时间以及血清药物浓度保持高于最低抑菌浓度（T＞MIC）的时间。两种抗菌药物的SBT持续时间和T＞MIC对所有分离株均超过给药间隔的50%。头孢唑肟的T＞MIC在统计学上高于头孢噻肟，这表明其血清半衰期（1.7小时）比头孢噻肟（约1小时）长，弥补了其对本研究中测试的耐青霉素肺炎球菌的微生物活性略低的不足。