用于治疗耐青霉素肺炎链球菌感染的口服β-内酰胺类抗生素的选择。
Choice of an oral beta-lactam antibiotic for infections due to penicillin-resistant Streptococcus pneumoniae.
作者信息
Goldstein F W
机构信息
Laboratoire de Microbiologie Médicale, Fondation Hôpital Saint-Joseph, Paris, France.
出版信息
Scand J Infect Dis. 1997;29(3):255-7. doi: 10.3109/00365549709019038.
The activity, pharmacokinetic and pharmacodynamic parameters of 5 oral beta-lactams have been compared against 400 penicillin-resistant Streptococcus pneumoniae (PRSP) isolated in 9 European countries. All the data have been calculated for the highest recommended oral dosage in France. Amoxicillin was by far the most effective antibiotic when considering its intrinsic activity (96% of the PRSP inhibited at 2 mg/l), the inhibitory quotient (100% of the PRSP > 1 vs 69.2% for cefuroxime) or a time above MIC > 40% which best correlates with clinical results (96% for amoxicillin vs < 25% for the cephalosporins).
已针对从9个欧洲国家分离出的400株耐青霉素肺炎链球菌（PRSP），比较了5种口服β-内酰胺类药物的活性、药代动力学和药效学参数。所有数据均按照法国最高推荐口服剂量计算得出。就其内在活性（2毫克/升时96%的PRSP被抑制）、抑制商数（PRSP>1时为100%，而头孢呋辛为69.2%）或高于最低抑菌浓度（MIC）的时间>40%（这与临床结果最相关，阿莫西林为96%，而头孢菌素类药物<25%）而言，阿莫西林是迄今为止最有效的抗生素。
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