Lindberg G, Iso H, Råstam L, Lundblad A, Folsom A R
NEPI Foundation, Medical Research Centre, Malmö University Hospital, Sweden.
Int J Epidemiol. 1997 Feb;26(1):58-63. doi: 10.1093/ije/26.1.58.
The concentration of serum total sialic acid (S-TSA) is one recently investigated risk marker for cardiovascular mortality and atherosclerosis. Since the mortality from coronary heart disease is higher in the United States than in Japan, one could expect the S-TSA to be higher among Caucasian US citizens than among Japanese citizens, a hypothesis that is tested in this study.
Cross-sectional study of population-based samples of Japanese and US Caucasian men and women.
The rural community Akita, Japan, and the suburbs of Minneapolis, Minnesota.
These were 75 consecutive men and women from Akita and Minneapolis respectively aged 47-69 years in 1990. People who had smoked cigarettes during the past 5 years; who had a history of diabetes mellitus, liver disease, coronary heart disease, or stroke; or who were taking anticoagulants were excluded.
Serum total sialic acid levels in male and female Japanese and US Caucasian subjects with adjustment for age, systolic blood pressure, fibrinogen, triglycerides and in women also for menopausal status. Race and sex-specific correlations with serum total sialic acid for selected cardiovascular risk markers.
The entire sialic acid distributions were shifted to the right in Caucasian men and women compared to Japanese men and women. The mean +/- standard deviation concentrations of S-TSA were 54.1 +/- 5.3 mg/dl in Japanese men and 58.7 +/- 5.6 mg/dl in Caucasian men (P < 0.001). In women, the concentrations were 54.8 +/- 5.1 and 63.1 +/- 6.0 mg/dl respectively (P < 0.001). S-TSA level correlated significantly and positively with fibrinogen levels in Caucasian and Japanese men and women and with triglyceride levels in Caucasian and Japanese men and in Caucasian women but not in Japanese women. After adjustment for age, systolic blood pressure, fibrinogen, triglycerides and menopausal status, the sialic acid levels were 2.2 (P = 0.009) and 6.2 (P < 0.001) mg/dl higher in Caucasian compared to Japanese men and women respectively.
Higher S-TSA levels in Caucasians living in Minneapolis compared to Japanese living in Akita, Japan is in concordance with the higher cardiovascular mortality in the US. Differences in S-TSA levels may reflect international differences in the prevalence of atherosclerosis.
血清总唾液酸（S - TSA）浓度是最近研究的心血管疾病死亡率和动脉粥样硬化的风险标志物。由于美国冠心病死亡率高于日本，因此可以预期美国白种人血清总唾液酸水平高于日本公民，本研究对这一假设进行了验证。
对日本和美国白种人男性及女性基于人群样本的横断面研究。
日本秋田农村社区以及明尼苏达州明尼阿波利斯郊区。
分别为1990年来自秋田和明尼阿波利斯的75名年龄在47 - 69岁的男性和女性。排除过去5年吸烟、有糖尿病、肝病、冠心病或中风病史或正在服用抗凝剂的人。
对日本和美国白种人男性及女性的血清总唾液酸水平进行年龄、收缩压、纤维蛋白原、甘油三酯校正，女性还进行绝经状态校正。对选定的心血管风险标志物与血清总唾液酸进行种族和性别特异性相关性分析。
与日本男性和女性相比，白种人男性和女性的总唾液酸分布均右移。日本男性S - TSA的平均±标准差浓度为54.1±5.3mg/dl，白种人男性为58.7±5.6mg/dl（P < 0.001）。女性浓度分别为54.8±5.1和63.1±6.0mg/dl（P < 0.001）。白种人和日本男性及女性中，S - TSA水平与纤维蛋白原水平显著正相关，在白种人和日本男性以及白种人女性中与甘油三酯水平显著正相关，但在日本女性中无此相关性。在对年龄、收缩压、纤维蛋白原、甘油三酯和绝经状态进行校正后，白种人男性和女性的唾液酸水平分别比日本男性和女性高2.2（P = 0.009）和6.2（P < 0.001）mg/dl。
与居住在日本秋田的日本人相比，居住在明尼阿波利斯的白种人S - TSA水平更高，这与美国较高的心血管疾病死亡率一致。S - TSA水平的差异可能反映了动脉粥样硬化患病率的国际差异。
