Hashiguchi K, Niki Y, Miyashita N, Kuroki M, Nakajima M, Kawane H, Matsushima T, Nishimura K
Department of Medicine, Kawasaki Medical School, Chiba University.
Kansenshogaku Zasshi. 1997 Mar;71(3):264-8. doi: 10.11150/kansenshogakuzasshi1970.71.264.
Cunninghamella bertholletiae, a rare causative agent of human deep seated mycosis, has been reported with increased frequency in the Western countries, in recent years. We experienced a case of Cunninghamella bertholletiae pulmonary infection in a 63-year-old male with pulmonary fibrosis and mild diabetes mellitus. In spite of intensive anti-fungal chemotherapy following clinical diagnosis, he died of exacerbation of the underlying diseases. Postmortem examination showed Cunninghamella infection in the cavity of the lung and massive pulmonary fibrosis. There was no fungal invasion outside the cavity. This is the third report of Cunninghamella human infection in Japan.
柏氏小克银汉霉是一种引起人类深部真菌病的罕见病原体，近年来在西方国家的报道频率有所增加。我们遇到一例63岁男性柏氏小克银汉霉肺部感染病例，该患者患有肺纤维化和轻度糖尿病。尽管临床诊断后进行了强化抗真菌化疗，但他最终死于基础疾病的加重。尸检显示肺部空洞内有柏氏小克银汉霉感染及大量肺纤维化。空洞外无真菌侵袭。这是日本第三例关于柏氏小克银汉霉人类感染的报告。
