Farnworth P G, Shulman A, Casey A T
Chem Biol Interact. 1977 Sep;18(3):289-94. doi: 10.1016/0009-2797(77)90015-1.
The actions of two related series of fully co-ordinated, divalent 1,10-phenanthroline transition metal chelates have been investigated on the rat isolated diaphragm muscle-phrenic nerve preparation and, where possible, compared with those of their constituent metal ions and ligands. Each member of both series of chelates produced blockade of neuromuscular transmission, although mechanistically not of a uniform type, and several elicited varying degrees of muscle contracture. The kinetic reactivity of the metal chelate appeared to be an important factor determining the nature of the biological response and profound differences in response were observed between labile and inert chelates differing in some cases by only one electron in the 3d shell.
研究了两个相关系列的完全配位的二价1,10-菲咯啉过渡金属螯合物对大鼠离体膈肌-膈神经标本的作用，并在可能的情况下，将其与它们的组成金属离子和配体的作用进行了比较。这两个系列螯合物的每个成员都产生了神经肌肉传递阻滞，尽管其机制并非统一类型，并且有几种引起了不同程度的肌肉挛缩。金属螯合物的动力学反应性似乎是决定生物学反应性质的一个重要因素，并且在3d壳层中某些情况下仅相差一个电子的不稳定和惰性螯合物之间观察到了反应上的深刻差异。
