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Differentiation and death of premyelinating oligodendrocytes in developing rodent brain.

作者信息

Trapp B D, Nishiyama A, Cheng D, Macklin W

机构信息

Department of Neurosciences, Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA.

出版信息

J Cell Biol. 1997 Apr 21;137(2):459-68. doi: 10.1083/jcb.137.2.459.

DOI:10.1083/jcb.137.2.459
PMID:9128255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139778/
Abstract

Previous studies have indicated that newly formed oligodendrocytes are dynamic cells whose production, survival, and differentiation depend upon axonal influences. This study has characterized the appearance and fate of newly formed oligodendrocytes in developing rat brain. Oligodendrocytes appear in predictable locations and radially extend DM-20-positive processes that cover 80-microm domains in the cortex and 40-microm domains in the corpus callosum. These premyelinating oligodendrocytes have one of two fates: they myelinate axons or degenerate. Between 7 and 21 d after birth, approximately 20% of premyelinating oligodendrocytes identified in the cerebral cortex were degenerating. Oligodendrocytes that ensheathed axons expressed and selectively targeted proteolipid protein to compact myelin and did not degenerate. These observations support the hypothesis that axonal influences affect oligodendrocyte survival, differentiation, and expression of proteolipid protein gene products.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/650a80a20899/JCB.trapp8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/6ef223c944e4/JCB.trapp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/4ebf745cb98b/JCB.trapp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/f86a08b8a8ee/JCB.trapp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/faffbac30786/JCB.trapp4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/77eedb648426/JCB.trapp5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/1a73fe9b6709/JCB.trapp6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/12b9d1299061/JCB.trapp7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/650a80a20899/JCB.trapp8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/6ef223c944e4/JCB.trapp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/4ebf745cb98b/JCB.trapp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/f86a08b8a8ee/JCB.trapp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/faffbac30786/JCB.trapp4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/77eedb648426/JCB.trapp5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/1a73fe9b6709/JCB.trapp6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/12b9d1299061/JCB.trapp7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3684/2139778/650a80a20899/JCB.trapp8.jpg

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本文引用的文献

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A division too far?
Curr Biol. 1992 Nov;2(11):577-9. doi: 10.1016/0960-9822(92)90150-9.
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Does oligodendrocyte survival depend on axons?少突胶质细胞的存活是否依赖于轴突？
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The oligodendrocyte and its many cellular processes.少突胶质细胞及其众多细胞突起。
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Transient Upregulation of Procaspase-3 during Oligodendrocyte Fate Decisions.少突胶质细胞命运决定过程中procaspase-3的瞬时上调
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