Clerici M, Piconi S, Balotta C, Trabattoni D, Capetti A, Fusi M L, Ruzzante S, Longhi R, Colombo M C, Moroni M, Milazzo F
Cattedra di Immunologia, Università degli Studi di Milano, Milan, Italy.
J Infect Dis. 1997 May;175(5):1210-5. doi: 10.1086/593570.
The effects of pentoxifylline on immunologic and virologic parameters were evaluated in 10 human immunodeficiency virus-infected patients not receiving antiretroviral treatment. Patients were asymptomatic, had 300-500 CD4 cells/microL, and received pentoxifylline (1200 mg/day orally) for 4 months. Peripheral blood mononuclear cells were tested before and at five time points during therapy. A transient increase in CD4 cells was observed in 8 of 9 patients, and CD8 cells increased in 7 of 9 patients. These increases were negatively correlated with susceptibility to in vitro mitogen-stimulated apoptotic cell death. Pentoxifylline had a temporary effect on mitogen-stimulated cytokine production; thus, interferon-gamma, interleukin (IL)-2, tumor necrosis factor-alpha, and lymphotoxin increased more than IL-10. Pentoxifylline also potentiated antigen-stimulated IL-2 production and proliferation in 8 of 9 patients and induced significant but transient decreases in plasma viremia in 7 of 9 patients. These preliminary findings suggest that pentoxifylline in vivo has an interesting but temporary influence on both immunologic and virologic parameters.
在10名未接受抗逆转录病毒治疗的人类免疫缺陷病毒感染患者中评估了己酮可可碱对免疫和病毒学参数的影响。患者无症状，CD4细胞计数为300 - 500个/微升，并接受己酮可可碱（口服1200毫克/天）治疗4个月。在治疗前及治疗期间的五个时间点对外周血单核细胞进行检测。9名患者中有8名观察到CD4细胞短暂增加，9名患者中有7名CD8细胞增加。这些增加与体外丝裂原刺激的凋亡细胞死亡易感性呈负相关。己酮可可碱对丝裂原刺激的细胞因子产生有暂时影响；因此，γ干扰素、白细胞介素（IL）-2、肿瘤坏死因子-α和淋巴毒素的增加超过IL-10。己酮可可碱还增强了9名患者中8名患者的抗原刺激的IL-2产生和增殖，并使9名患者中7名患者的血浆病毒血症显著但短暂降低。这些初步发现表明，己酮可可碱在体内对免疫和病毒学参数有有趣但暂时的影响。
