Herwaldt B L, Kjemtrup A M, Conrad P A, Barnes R C, Wilson M, McCarthy M G, Sayers M H, Eberhard M L
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA.
J Infect Dis. 1997 May;175(5):1259-62. doi: 10.1086/593812.
Most cases of babesiosis reported in the United States have been tickborne and caused by Babesia microti, the etiologic agent of all previously described transfusion-transmitted cases. A 76-year-old man with the first recognized case of transfusion-transmitted infection with the recently identified WA1-type Babesia parasite is described. The subject received multiple blood transfusions in 1994. Indirect immunofluorescent antibody testing of serum from 57 blood donors implicated a 34-year-old man (WA1 titer, 1:65,536) whose donation had been used for packed red cells. Isolates of the organisms that infected the recipient and the donor, both of whom were spleen-intact residents of Washington State, were obtained by hamster inoculation. The DNA sequence of a 536-bp region of the nuclear small subunit-rRNA gene of both isolates was identical to that of WA1 (isolated in 1991 from the index WA1 case-patient). Effective measures for preventing transmission of babesiosis by blood transfusion are needed.
在美国报告的大多数巴贝斯虫病病例都是通过蜱传播的，由微小巴贝斯虫引起，这是所有先前描述的输血传播病例的病原体。本文描述了一名76岁男性，他是首例被确认感染了最近发现的WA1型巴贝斯虫寄生虫的输血传播感染病例。该患者在1994年接受了多次输血。对57名献血者血清进行的间接免疫荧光抗体检测显示，一名34岁男性（WA1滴度为1:65,536）的献血被用于制备浓缩红细胞，该献血者与此有关。通过仓鼠接种获得了感染受血者和献血者的病原体分离株，这两人都是华盛顿州脾脏健全的居民。两个分离株的核小亚基核糖体RNA基因536bp区域的DNA序列与WA1（1991年从首例WA1病例患者分离得到）相同。需要采取有效的措施来预防输血传播巴贝斯虫病。
